[多粘菌素的结构与功能研究。多粘菌素M在水中构象的1H核磁共振分析]
[Structural and functional research on polymyxins. 1H NMR analysis of the conformation of polymyxin M in water].
作者信息
Okhanov V V, Dubovskiĭ P V, Trakhanova M N, Bairamashvili D I, Zinchenko A A
出版信息
Antibiot Med Biotekhnol. 1987 Oct;32(10):738-43.
Spatial structure of polypeptide antibiotic polymyxin M in water was studied by one-and two-dimensional (COSY, COSY-45, RELAY) H NMR spectroscopy. Analysis of the signal spectral parameters revealed two intramolecular hydrogen bonds in the cyclic part of the molecule which was analogous to the structure of polymyxin B. However, configuration of both the beta-turns in the polymyxin M structure differed from that of the detected earlier beta-turns in the structure of polymyxin B.
通过一维和二维（COSY、COSY-45、RELAY）氢核磁共振光谱研究了多肽抗生素多粘菌素M在水中的空间结构。对信号光谱参数的分析揭示了该分子环状部分存在两个分子内氢键，这与多粘菌素B的结构类似。然而，多粘菌素M结构中两个β-转角的构型与先前在多粘菌素B结构中检测到的β-转角构型不同。
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