Cabezas-Cruz Alejandro, Mateos-Hernández Lourdes, Alberdi Pilar, Villar Margarita, Riveau Gilles, Hermann Emmanuel, Schacht Anne-Marie, Khalife Jamal, Correia-Neves Margarida, Gortazar Christian, de la Fuente José
Center for Infection and Immunity of Lille (CIIL), Université Lille Nord de France, Institut Pasteur de Lille, Lille, France.
SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ronda de Toledo s/n, Ciudad Real, Spain.
Exp Mol Med. 2017 Mar 10;49(3):e301. doi: 10.1038/emm.2016.164.
The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to α-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying α-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with α-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without α-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-α-Gal antibody protective response. These results have implications for disease control and prevention.
确定影响传染病易感性的因素对于减轻其对人类群体的负担至关重要。ABO血型与疟疾和其他传染病的易感性相关。由于血液抗原B与Galα1-3Galβ1-(3)4GlcNAc-R（α-Gal）之间存在结构相似性，我们推测对抗原B的自身耐受性会影响对α-Gal的免疫反应，进而影响对表面携带α-Gal的病原体引起的传染病的易感性。在这里，我们发现由表面带有α-Gal的病原体引起的疟疾和结核病的发病率与流行地区B血型的频率呈正相关。然而，由不含α-Gal的病原体引起的登革热的发病率与这些人群中B血型的频率无关。此外，疟疾和结核病的发病率与抗α-Gal抗体保护反应呈负相关。这些结果对疾病的控制和预防具有启示意义。
