CCL21在神经胶质瘤免疫监视和免疫治疗中作用的见解。

Insights into CCL21's roles in immunosurveillance and immunotherapy for gliomas.

作者信息

Nguyen Thien, Lagman Carlito, Chung Lawrance K, Chen Cheng Hao Jacky, Poon Jessica, Ong Vera, Voth Brittany L, Yang Isaac

机构信息

Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States.

出版信息

J Neuroimmunol. 2017 Apr 15;305:29-34. doi: 10.1016/j.jneuroim.2017.01.010. Epub 2017 Jan 18.

DOI:10.1016/j.jneuroim.2017.01.010

PMID:28284342

Abstract

Chemokine (C-C) motif ligand 21 (CCL21) is involved in immunosurveillance and has recently garnered the attention of neuro-oncologists and neuroscientists. CCL21 contains an extended C-terminus, which increases binding to lymphatic glycosaminoglycans and provides a mechanism for cell trafficking by forming a stationary chemokine concentration gradient that allows cell migration via haptotaxis. CCL21 is expressed by endothelial cells of the blood-brain barrier in physiologic and pathologic conditions. CCL21 has also been implicated in leukocyte extravasation into the central nervous system. In this review, we summarize the role of CCL21 in immunosurveillance and explore its potential as an immunotherapeutic agent for the treatment of gliomas.

摘要

趋化因子（C-C）基序配体21（CCL21）参与免疫监视，最近引起了神经肿瘤学家和神经科学家的关注。CCL21含有一个延长的C末端，这增加了与淋巴糖胺聚糖的结合，并通过形成一个稳定的趋化因子浓度梯度为细胞运输提供了一种机制，该梯度允许细胞通过趋触性迁移。在生理和病理条件下，血脑屏障的内皮细胞会表达CCL21。CCL21也与白细胞渗入中枢神经系统有关。在这篇综述中，我们总结了CCL21在免疫监视中的作用，并探讨了其作为治疗神经胶质瘤的免疫治疗剂的潜力。