Krougly L B, Fomicheva O A, Karpov Yu A, Popkova T V, Novikova D S, Nasonov E L
Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.
V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
Kardiologiia. 2016 Jun;56(6):89-95. doi: 10.18565/cardio.2016.6.89-95.
Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with high risk of cardiovascular events. Among main causes of death in RA are: myocardial infarction, cerebrovascular accident, sudden cardiac death, which are determined by the early development and rapid progression of atherosclerotic vascular lesions. According to studies high risk of cardiovascular events is not explained by only classical risk factors. It is assumed that there are additional mechanisms of development of adverse outcomes such as systemic inflammation, increased arterial stiffness, and endothelial dysfunction. In this literature review we present various risk factors of cardiovascular events in patients with RA and their relation to RA pathogenesis.
类风湿关节炎（RA）是一种与心血管事件高风险相关的慢性炎症性疾病。RA患者的主要死因包括：心肌梗死、脑血管意外、心源性猝死，这些均由动脉粥样硬化性血管病变的早期发展和快速进展所决定。根据研究，心血管事件的高风险并不能仅由经典危险因素来解释。据推测，还存在其他导致不良后果的机制，如全身炎症、动脉僵硬度增加和内皮功能障碍。在这篇文献综述中，我们阐述了RA患者心血管事件的各种危险因素及其与RA发病机制的关系。
