Indraratna Praveen, Alexopoulos Chris, Celermajer David, Alford Kevin
Department of Cardiology, Prince of Wales Hospital, Sydney, NSW, Australia; University of New South Wales, Sydney, NSW, Australia.
University of New South Wales, Sydney, NSW, Australia; Department of Cardiology, Port Macquarie Base Hospital, Port Macquarie, NSW, Australia.
Heart Lung Circ. 2017 Aug;26(8):e41-e43. doi: 10.1016/j.hlc.2017.01.019. Epub 2017 Mar 6.
A 28-year-old male was admitted to hospital with an acute ST-elevation myocardial infarction. This was in the context of recreational abuse of nitrous oxide. The prevalence of nitrous oxide use in Australia has not been formally quantified, however it is the second most commonly used recreational drug in the United Kingdom. Nitrous oxide has previously been shown to increase serum homocysteine levels. This patient was discovered to have an elevated homocysteine level at baseline, which was further increased after nitrous oxide consumption. Homocysteine has been linked to endothelial dysfunction and coronary atherosclerosis and this case report highlights one of the dangers of recreational abuse of nitrous oxide.
一名28岁男性因急性ST段抬高型心肌梗死入院。这是在滥用笑气进行娱乐的背景下发生的。澳大利亚笑气使用的流行率尚未得到正式量化，然而它是英国第二常用的娱乐性药物。先前已表明笑气会增加血清同型半胱氨酸水平。该患者在基线时被发现同型半胱氨酸水平升高，在摄入笑气后进一步升高。同型半胱氨酸与内皮功能障碍和冠状动脉粥样硬化有关，本病例报告突出了滥用笑气进行娱乐的危险之一。
