Kamyab Kambiz, Kazemi Sheyda, Azimi Pourya, Azizpour Arghavan, Ghandi Narges, Pirooz Elham, Noormohammadpour Pedram, Mirshams-Shahshahani Mostafa, Daneshpazhooh Maryam
Department of Dermatopathology, Tehran University of Medical Sciences, Tehran, Iran.
Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
Australas J Dermatol. 2017 Nov;58(4):e228-e231. doi: 10.1111/ajd.12616. Epub 2017 Mar 15.
BACKGROUND/OBJECTIVES: The characteristics of cutaneous melanoma in the Middle-Eastern countries is poorly described. Therefore we conducted this study to determine the characteristics of melanoma in Iran.
A retrospective, cross sectional study of melanoma patients seen at a tertiary referral centre, Iran, from May 2004 to October 2014. Clinical data included age and gender of the patients at the time of diagnosis, tumour location and tumour size. Histological characteristics included Breslow thickness, Clark level and subtype of tumour.
A total of 450 cases of melanoma with a male/female ratio of 1.1:1 were reviewed. The mean age of patients was 57.5 years. The most frequent histological subtypes were acral lentiginous melanoma (30%) and lentigo maligna melanoma (29%). In 215 cases (49%) the tumour was located on the extremities. The second most common site was the face. Tumour invasion was mainly at Clark level III and IV. The mean Breslow thickness was 2.8 mm; 143 (38%) melanomas had a Breslow thickness less than 1 mm (T1) and 86 (23%) were more than 4 mm (T4).
This study indicates that clinical and histological features of melanoma in Iranians (who are mainly of skin phototypes 3-4) are different from those observed in Western countries. Further cohort studies are required to evaluate the role of ethnic and environmental risk factors for melanoma in different populations.
背景/目的：中东国家皮肤黑色素瘤的特征描述甚少。因此，我们开展了本研究以确定伊朗黑色素瘤的特征。
对2004年5月至2014年10月期间在伊朗一家三级转诊中心就诊的黑色素瘤患者进行回顾性横断面研究。临床数据包括诊断时患者的年龄和性别、肿瘤位置及肿瘤大小。组织学特征包括Breslow厚度、Clark分级及肿瘤亚型。
共回顾了450例黑色素瘤病例，男女比例为1.1:1。患者的平均年龄为57.5岁。最常见的组织学亚型为肢端雀斑样痣黑色素瘤（30%）和恶性雀斑样痣黑色素瘤（29%）。215例（49%）肿瘤位于四肢。第二常见部位是面部。肿瘤浸润主要处于Clark III级和IV级。平均Breslow厚度为2.8 mm；143例（38%）黑色素瘤的Breslow厚度小于1 mm（T1），86例（23%）大于4 mm（T4）。
本研究表明，伊朗人（主要为皮肤光型3 - 4）黑色素瘤的临床和组织学特征与西方国家观察到的不同。需要进一步开展队列研究以评估种族和环境危险因素在不同人群中对黑色素瘤的作用。
