iChEM, State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P.R. China.
Angew Chem Int Ed Engl. 2017 Apr 18;56(17):4734-4738. doi: 10.1002/anie.201701329. Epub 2017 Mar 13.
Reported herein is an unprecedented synthesis of C3-fluorinated oxindoles through cross-dehydrogenative coupling of C(sp )-H and C(sp )-H bonds from malonate amides. Under the unique and mild electrochemical conditions, the requisite oxidant and base are generated in a continuous fashion, allowing the formation of the base- and heat-sensitive 3-fluorooxindoles in high efficiency with broad substrate scope. The synthetic usefulness of the electrochemical method is further highlighted by its easy scalability and the diverse transformations of the electrolysis product.
本文报道了一种通过丙二酸酰胺的 C(sp )-H 和 C(sp )-H 键的交叉脱氢偶联来合成 C3-氟化氧吲哚的新方法。在独特而温和的电化学条件下，所需的氧化剂和碱连续生成，从而以高效率和广泛的底物范围形成了对碱和热敏感的 3-氟氧吲哚。该电化学方法的合成实用性还通过其易于规模化和电解产物的多样化转化得到了进一步的证明。
