A novel p53-Cdc7 link induced by genotoxic stress.
作者信息
Masai Hisao
机构信息
a Department of Genome Medicine , Tokyo Metropolitan Institute of Medical Science , Setagaya-ku, Tokyo , Japan.
出版信息
Cell Cycle. 2017 Apr 18;16(8):735-736. doi: 10.1080/15384101.2017.1304746. Epub 2017 Mar 15.
Abstract
摘要
相似文献
1
A novel p53-Cdc7 link induced by genotoxic stress.由基因毒性应激诱导的一种新型p53-Cdc7联系。
Cell Cycle. 2017 Apr 18;16(8):735-736. doi: 10.1080/15384101.2017.1304746. Epub 2017 Mar 15.
2
p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.p53 控制 CDC7 的水平，以在基因毒性应激时加强 G1 期细胞周期阻滞。
Cell Cycle. 2016 Nov;15(21):2958-2972. doi: 10.1080/15384101.2016.1231281. Epub 2016 Sep 9.
3
Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints.p53和ATM基因产物在G1/S和S期检查点调控中的要求。
Oncogene. 1998 Feb 12;16(6):721-36. doi: 10.1038/sj.onc.1201793.
4
Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition.p53/p21Cip1/WAF1 依赖性 DNA 损伤检查点信号导致核蛋白 ICBP90 下调，从而促使细胞周期在 G1/S 转换期停滞。
Genes Cells. 2004 Feb;9(2):131-42. doi: 10.1111/j.1356-9597.2004.00710.x.
5
Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells.p53 缺失会抑制 G1/S 检验点缺陷细胞中复制应激诱导的 DNA 断裂。
Elife. 2018 Oct 16;7:e37868. doi: 10.7554/eLife.37868.
6
The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.p53-p21WAF1 检查点途径在防止因 FOXF1 功能丧失而导致的 DNA 重复制中发挥保护作用。
Cell Signal. 2012 Jan;24(1):316-24. doi: 10.1016/j.cellsig.2011.09.017. Epub 2011 Sep 22.
7
Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage.Cdk2 增强了细胞内 S 期检查点，抵消了由 DNA 损伤诱导的细胞周期退出。
Sci Rep. 2017 Oct 18;7(1):13429. doi: 10.1038/s41598-017-12868-5.
8
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.CDK2 在人胚胎干细胞 G1 期到 S 期检验点激活和 DNA 损伤反应中的重要作用。
Stem Cells. 2011 Apr;29(4):651-9. doi: 10.1002/stem.620.
9
CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage.CDK4 抑制在多柔比星诱导的 DNA 损伤情况下恢复 MYCN 扩增神经母细胞瘤细胞的 G1-S 期阻滞。
Cell Cycle. 2013 Apr 1;12(7):1091-104. doi: 10.4161/cc.24091. Epub 2013 Mar 5.
10
Pathways governing G1/S transition and their response to DNA damage.调控G1/S期转换的信号通路及其对DNA损伤的反应。
FEBS Lett. 2001 Feb 16;490(3):117-22. doi: 10.1016/s0014-5793(01)02114-7.
引用本文的文献
1
CDC7 as a novel biomarker and druggable target in cancer.CDC7 作为癌症的新型生物标志物和可用药靶。
Clin Transl Oncol. 2022 Oct;24(10):1856-1864. doi: 10.1007/s12094-022-02853-4. Epub 2022 Jun 3.
本文引用的文献
1
p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.p53 控制 CDC7 的水平，以在基因毒性应激时加强 G1 期细胞周期阻滞。
Cell Cycle. 2016 Nov;15(21):2958-2972. doi: 10.1080/15384101.2016.1231281. Epub 2016 Sep 9.
2
Regulation and roles of Cdc7 kinase under replication stress.复制应激下Cdc7激酶的调控及作用
Cell Cycle. 2014;13(12):1859-66. doi: 10.4161/cc.29251. Epub 2014 May 19.
3
Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.Hsk1 激酶和 Cdc45 调节裂殖酵母中复制压力诱导的检查点反应。
Cell Cycle. 2010 Dec 1;9(23):4627-37. doi: 10.4161/cc.9.23.13937.
4
Damage-induced phosphorylation of Sld3 is important to block late origin firing.损伤诱导的 Sld3 磷酸化对于阻止晚期起始原点的激活很重要。
Nature. 2010 Sep 23;467(7314):479-83. doi: 10.1038/nature09377.
5
Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation.Sld3 和 Dbf4 磷酸化依赖检验点抑制 DNA 复制起始。
Nature. 2010 Sep 23;467(7314):474-8. doi: 10.1038/nature09373. Epub 2010 Sep 12.
6
Molecular architecture of the DNA replication origin activation checkpoint.DNA 复制起始激活检查点的分子结构。
EMBO J. 2010 Oct 6;29(19):3381-94. doi: 10.1038/emboj.2010.201. Epub 2010 Aug 20.
7
Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.细胞周期蛋白依赖性激酶7（Cdc7激酶）在DNA复制检查点中介导Claspin蛋白的磷酸化。
Oncogene. 2008 May 29;27(24):3475-82. doi: 10.1038/sj.onc.1210994. Epub 2007 Dec 17.
Zotero 插件