Kretzschmar Kai, Clevers Hans
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, Utrecht, The Netherlands.
Cancer Genomics Netherlands, UMC Utrecht, Utrecht, The Netherlands.
EMBO J. 2017 Apr 3;36(7):837-839. doi: 10.15252/embj.201796482. Epub 2017 Mar 15.
While adult intestinal stem cells and their niche are well characterised, their developmental specification is still poorly understood. In this issue of , Nigmatullina (2017) show that maturation of Lgr5 progenitors in the small intestinal epithelium during murine embryonic development is controlled by the transcription factor Id2.
虽然成体肠道干细胞及其生态位已得到充分表征,但其发育特化仍知之甚少。在本期杂志中,Nigmatullina(2017年)表明,小鼠胚胎发育期间小肠上皮中Lgr5祖细胞的成熟受转录因子Id2控制。