Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
J Magn Reson Imaging. 2017 Dec;46(6):1767-1775. doi: 10.1002/jmri.25705. Epub 2017 Mar 16.
To compare a faster diagonal diffusion-weighted imaging (d-DWI) to conventional three-scan trace DWI (t-DWI) acquisition for prostate magnetic resonance imaging (MRI) in terms of image quality, tumor detection/conspicuity, Prostate Imaging Reporting and Data System (PI-RADS) characterization, quantitative estimated signal-to-noise ratio (eSNR), and apparent diffusion coefficient (ADC) measurement.
A total of 34 consecutive men with suspected prostate cancer (PCa) who underwent 3T MRI of the prostate were assessed. MRI included t-DWI and d-DWI (using b-values of 50, 1000, and 1600 s/mm , number of averages 1/5/10 for t-DWI vs. 2/8/14 for d-DWI, acquisition time 6:21 min vs. 4:17 min, respectively). Two independent observers evaluated image quality, including image sharpness, anatomic distortion, and artifacts on a 5-point scale (1-5) and assessed tumor detection, conspicuity, and PI-RADS classification with both DWI sequences. eSNR and ADC were measured in the peripheral zone (PZ), transitional zone (TZ), and detected tumors. Data was compared using paired Wilcoxon signed rank tests and McNemar test. Coefficients of variations (CV) between ADC obtained with both sequences were calculated.
Significantly fewer artifacts were observed on d-DWI at b 1600 for observer 2 (P < 0.01), while the other image quality scores were equivalent for both sequences. eSNR was lower with d-DWI vs. t-DWI in PZ and TZ for b 1000 (P < 0.01 and P = 0.03, respectively) and b 1600 (P < 0.01 for both). ADC reproducibility between sequences was excellent (CV <10%). No significant differences were found for tumor detection (P ≥ 0.25), conspicuity (P ≥ 0.12), or PI-RADS classification (P ≥ 0.10).
d-DWI can provide a substantial reduction in acquisition time (∼30%) while maintaining equivalent tumor detection, PI-RADS score, image quality, and ADC values.
3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1767-1775.
比较快速对角线扩散加权成像（d-DWI）与传统三扫描轨迹扩散加权成像（t-DWI）在前列腺磁共振成像（MRI）中的图像质量、肿瘤检测/显著性、前列腺影像报告和数据系统（PI-RADS）特征、定量估计信噪比（eSNR）和表观扩散系数（ADC）测量方面的差异。
共评估了 34 例疑似前列腺癌（PCa）的连续男性患者，他们接受了 3T 前列腺 MRI 检查。MRI 包括 t-DWI 和 d-DWI（b 值分别为 50、1000 和 1600 s/mm，平均次数分别为 1/5/10 次和 2/8/14 次，采集时间分别为 6:21 min 和 4:17 min）。两位独立观察者使用 5 分制（1-5 分）评估图像质量，包括图像清晰度、解剖变形和伪影，并使用两种 DWI 序列评估肿瘤检测、显著性和 PI-RADS 分类。在周围区（PZ）、移行区（TZ）和检测到的肿瘤中测量 eSNR 和 ADC。使用配对 Wilcoxon 符号秩检验和 McNemar 检验比较数据。计算两种序列获得的 ADC 之间的变异系数（CV）。
观察者 2 在 b 值为 1600 时，d-DWI 上的伪影明显少于 t-DWI（P<0.01），而其他图像质量评分在两种序列之间是等效的。在 b 值为 1000（P<0.01 和 P=0.03）和 b 值为 1600（P<0.01）时，d-DWI 的 eSNR 低于 t-DWI 在 PZ 和 TZ。序列之间的 ADC 可重复性非常好（CV<10%）。在肿瘤检测（P≥0.25）、显著性（P≥0.12）或 PI-RADS 分类（P≥0.10）方面均未发现显著差异。
d-DWI 可以显著减少采集时间（约 30%），同时保持等效的肿瘤检测、PI-RADS 评分、图像质量和 ADC 值。
3 级技术功效：第 2 阶段 J. Magn. Reson. Imaging 2017;46:1767-1775.
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