Scarpa Mariagiovanna, Stegemann Sven, Hsiao Wen-Kai, Pichler Heinz, Gaisford Simon, Bresciani Massimo, Paudel Amrit, Orlu Mine
School of Pharmacy, University College London (UCL), London, United Kingdom.
Graz University of Technology, Graz, Austria.
Int J Pharm. 2017 May 15;523(1):327-335. doi: 10.1016/j.ijpharm.2017.03.018. Epub 2017 Mar 14.
Orodispersible films (ODF) hold promise as a novel delivery method, with the potential to deliver tailored therapies to different patient populations. This article reviews the current strides of ODF technology and some of its unmet quality and manufacturing aspects. A topic highlights opportunities and limitations of inkjet printed ODF as a population-specific drug delivery. Overall, this article aims to stimulate further research to fill the current knowledge gap between manufacturing and administration requirements of ODF targeting specific patient subpopulations such as geriatrics.
口腔崩解膜(ODF)作为一种新型给药方法具有广阔前景,有潜力为不同患者群体提供定制化治疗。本文综述了ODF技术的当前进展及其一些尚未满足的质量和制造方面的问题。一个主题突出了喷墨打印ODF作为针对特定人群的药物递送方式的机遇和局限性。总体而言,本文旨在激发进一步的研究,以填补目前在针对老年患者等特定患者亚群的ODF制造与给药要求之间的知识空白。