Connelly Thomas G
Department of Anatomy and Center for Human Growth and Development, The University of Michigan, 48109, Ann Arbor, Michigan, USA.
Wilehm Roux Arch Dev Biol. 1977 Jun;181(2):103-106. doi: 10.1007/BF00848434.
Following lentectomy newts were injected with indomethacin in a variety of carrier solutions at doses ranging from 1.2-120 mg/kg body weight every other day for 15-17 days. The results show that injection of this drug according to the regimen used has no significant effect on regeneration of the lens. The data suggest, but do not prove, that prostaglandins may not play a major role in the early phases of lens regeneration in the newt.
晶状体切除术后,每隔一天给蝾螈注射吲哚美辛,剂量范围为1.2 - 120毫克/千克体重,注射于多种载体溶液中,持续15 - 17天。结果表明,按照所采用的方案注射这种药物对晶状体再生没有显著影响。数据表明,但未证实,前列腺素可能在蝾螈晶状体再生的早期阶段不发挥主要作用。