Veisa Gabriel, Tasmoc Alexandra, Nistor Ionut, Segall Liviu, Siriopol Dimitrie, Solomon Sorina Mihaela, Donciu Mihaela Dora, Voroneanu Luminita, Nastasa Andra, Covic Adrian
Nephrology Department, Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa", Iasi, Romania.
Dialysis and Renal Transplantation Center, "Dr. C. I. Parhon" University Hospital, Iasi, Romania.
Int Urol Nephrol. 2017 Jul;49(7):1261-1266. doi: 10.1007/s11255-017-1571-5. Epub 2017 Mar 18.
Periodontal disease is a chronic infectious disease. Individuals with end-stage kidney disease (ESKD) experience impaired quality of life (QoL) and low oral health. This is the first comprehensive study which aimed to explore the link between periodontal disease and quality of life, assessed with the Short Form 36-Item Health Survey in hemodialysis patients.
In total, 101 patients (57 females) with ESKD were recruited from two Romanian dialysis centers. Periodontal disease assessment included the measurement of periodontal disease index, with its three components: the gingival and periodontal index (GP), the bacterial plaque index (PI) and the calculus index (CI). For assessing QoL, we used the Short Form 36-Item Health Survey (SF-36), with its two components: physical component (PCS) and mental component (MCS).
The mean age was 52.5 ± 14.3 years. The dialysis vintage was 6.7 ± 5.6 years. According to periodontal status, the mean value of GP was 4.0 ± 1.3, mean PI was 1.8 ± 0.9, and mean CI was 1.3 ± 0.7. Regarding the QoL, the means for PCS and MCS were 38.0 ± 17.3 and 45.0 ± 16.3, respectively. In univariate analysis, the physical and mental components of QoL were significantly associated with the gingival and periodontal index, the bacterial plaque index and the calculus index. In the multivariable linear regression, only the gingival and periodontal index remained significantly associated with physical component (β = -3.26, p = 0.04, 95% CI -6.39 to -0.13) and mental component (β = -5.57, p = 0.001, 95% CI -8.74 to -2.41) of QoL.
Our study shows a high prevalence and severity of periodontal disease. The gingival and periodontal index was associated with low QoL, both on physical and on mental components.
牙周病是一种慢性感染性疾病。终末期肾病（ESKD）患者生活质量受损，口腔健康状况不佳。这是第一项全面研究，旨在探讨牙周病与生活质量之间的联系，采用36项简短健康调查问卷对血液透析患者进行评估。
从罗马尼亚的两个透析中心招募了101例ESKD患者（57例女性）。牙周病评估包括牙周病指数的测量，其三个组成部分为：牙龈与牙周指数（GP）、菌斑指数（PI）和牙石指数（CI）。为评估生活质量，我们使用了36项简短健康调查问卷（SF-36），其两个组成部分为：身体成分（PCS）和心理成分（MCS）。
平均年龄为52.5±14.3岁。透析时间为6.7±5.6年。根据牙周状况，GP的平均值为4.0±1.3，PI的平均值为1.8±0.9，CI的平均值为1.3±0.7。关于生活质量，PCS和MCS的平均值分别为38.0±17.3和45.0±16.3。在单变量分析中，生活质量的身体和心理成分与牙龈与牙周指数、菌斑指数和牙石指数显著相关。在多变量线性回归中，只有牙龈与牙周指数与生活质量的身体成分（β=-3.26，p=0.04，95%CI -6.39至-0.13）和心理成分（β=-5.57，p=0.001，95%CI -8.74至-2.41）仍显著相关。
我们的研究表明牙周病的患病率和严重程度较高。牙龈与牙周指数与身体和心理成分的低生活质量相关。
