间充质基质细胞增强多发性骨髓瘤髓系来源抑制细胞的抑制作用。
Mesenchymal stromal cells enhance the suppressive effects ofmyeloid-derived suppressor cells of multiple myeloma.
作者信息
Xu Yinhui, Zhang Xiaoying, Liu Hongbo, Zhao Pan, Chen Yafang, Luo Yimin, Zhang Zhiqing, Wang Xiaofang
机构信息
a Thoracic Surgery , The Second Affiliated Hospital of Guilin Medical University , Guilin, Guangxi , China.
b Department of Hematology, Key Laboratory of Cancer Prevention and Therapy , Cancer Hospital of Tianjin, Tianjin Medical University , Tianjin , China.
出版信息
Leuk Lymphoma. 2017 Nov;58(11):2668-2676. doi: 10.1080/10428194.2017.1298753. Epub 2017 Mar 20.
Both mesenchymal stromal cells (MSCs) and myeloid-derived suppressor cells (MDSCs) have immunosuppressive properties, and their presence may confer a worse prognosis upon cancer patients. However, whether MSCs can enhance the immunosuppressive effects of MDSCs in MM remains unknown. We evaluated the influence of MSCs on MDSCs growth, apoptosis, and functions. Our results show that MSCs promote proliferation and inhibit apoptosis in MDSCs. Additionally, MSCs enhance the ability of MDSCs by inhibiting T-cell proliferation and IFN-γ production. Furthermore, both the mRNA and protein levels of Arg1 and NOS2 were upregulated in MDSCs. These results suggest that MSCs may exert immunomodulatory effects on MDSCs by upregulating Arg1 and NOS2.
间充质基质细胞（MSCs）和髓源性抑制细胞（MDSCs）都具有免疫抑制特性，它们的存在可能会使癌症患者的预后更差。然而，在多发性骨髓瘤（MM）中，MSCs是否能增强MDSCs的免疫抑制作用仍不清楚。我们评估了MSCs对MDSCs生长、凋亡及功能的影响。我们的结果表明，MSCs促进MDSCs增殖并抑制其凋亡。此外，MSCs通过抑制T细胞增殖和干扰素-γ（IFN-γ）产生来增强MDSCs的能力。此外，MDSCs中精氨酸酶1（Arg1）和一氧化氮合酶2（NOS2）的mRNA和蛋白水平均上调。这些结果表明，MSCs可能通过上调Arg1和NOS2对MDSCs发挥免疫调节作用。
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