Snover D C, Hutton S, Balfour H H, Bloomer J R
Liver Center, University of Minnesota Medical School, Minneapolis 55455.
J Clin Gastroenterol. 1987 Dec;9(6):659-65. doi: 10.1097/00004836-198712000-00010.
Thirty-two transplant recipients with cytomegalovirus (CMV) infection documented by positive culture of blood and/or organs other than the liver were evaluated for hepatic involvement. Thirteen of the 32 (41%) had evidence of hepatic involvement with CMV. Inclusions alone were present in three patients; liver cultures alone were positive for CMV in three; and both were present in seven. Although the presence of CMV inclusions was the only histological feature that clearly separated the groups with and without hepatic involvement, two items helpful in finding inclusions were lobular aggregates of polymorphonuclear cells and portal karyorrhexic debris. The presence of liver involvement had a significant correlation with multiple organ infection, indicating it is a good marker of widely disseminated disease. This study indicates that liver histology and culture are useful and complementary methods for documentation of hepatic involvement (hence, tissue invasion) in immunocompromised patients with CMV infection.
对32名通过血液和/或肝脏以外器官的培养呈阳性记录为巨细胞病毒（CMV）感染的移植受者进行了肝脏受累情况评估。32名患者中有13名（41%）有CMV肝脏受累的证据。仅包涵体出现在3名患者中；仅肝脏培养CMV呈阳性的有3名；两者都有的有7名。虽然CMV包涵体的存在是唯一能明确区分有和没有肝脏受累组的组织学特征，但有助于发现包涵体的两个特征是多形核细胞的小叶聚集和门脉核溶解碎片。肝脏受累与多器官感染有显著相关性，表明它是广泛播散性疾病的一个良好标志。这项研究表明，肝脏组织学和培养是记录CMV感染免疫受损患者肝脏受累（即组织侵袭）的有用且互补的方法。
