Cai Xiong-Jie, Li Zhi, Chen Wen-Hua
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Bioorg Med Chem Lett. 2017 May 1;27(9):1999-2002. doi: 10.1016/j.bmcl.2017.03.024. Epub 2017 Mar 10.
Two tripodal squaramide conjugates having 4-(trifluoromethyl)phenyl and 3,5-bis(trifluoromethyl)phenyl substituents were synthesized and found to exhibit highly efficient transmembrane anion transport with the EC values being 0.14 and 0.75mol%, respectively. Though one of them has been reported to act as a strong anion receptor, in particular for sulfate anions, these two compounds exhibit no significant selectivity with respect to the tested monovalent anions and a very low level of activity in the presence of sulfate anions.
合成了两种具有4-（三氟甲基）苯基和3,5-双（三氟甲基）苯基取代基的三脚架方酰胺共轭物，发现它们表现出高效的跨膜阴离子转运，其EC值分别为0.14和0.75mol%。尽管其中一种已被报道可作为强阴离子受体，特别是对硫酸根阴离子，但这两种化合物对测试的单价阴离子没有明显的选择性，并且在硫酸根阴离子存在下活性水平非常低。
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