[细胞块细针穿刺在腮腺肿块诊断中的临床疗效]
[Clinical efficacy of the fine needle aspiration of the cell block in the diagnosis of parotid gland masses].
作者信息
Hong Chen, Qingquan Fang, Jinhua Tu, Qiaoling Cai, Suhua Zhang
机构信息
Pharmaceutical Department, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
Dept. of Pathology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Oct 1;34(5):483-487. doi: 10.7518/hxkq.2016.05.010.
OBJECTIVE
To investigate the clinical significance of cell blocks obtained by ultrasound-guided fine needle aspiration in diagnosing parotid gland masses.
METHODS
Cell blocks were made in 285 parotid gland masses by ultrasound-guided fine needle aspiration. Diagnosis was conducted using the cell blocks. Non-tumor masses were subjected to conservative treatment, and cysts and tumors were treated with surgery. The cell block sections from masses with the diagnosis of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) were applied to the detection of immunocytochemical staining for the stem cell factor receptor CD117.
RESULTS
The satisfaction rate of the specimen was 95.1% (271/285). The accuracy rate of the diagnosis was 94.5% (256/271), the sensitivity was 87.0% (67/77), and the specificity was 98.1% (157/160). The positive rate of CD117 in ACC was 95.2% (20/21), whereas that in PA was 20.3% (25/123). The positive rate of CD117 in ACC was higher than that in PA (P<0.01).
CONCLUSIONS: The use of cell blocks obtained from ultrasound-guided fine needle aspiration, together with molecular marker detection, has great significance in diagnosing parotid gland masses. .
目的
探讨超声引导下细针穿刺获取的细胞块在腮腺肿块诊断中的临床意义。
方法
对285例腮腺肿块进行超声引导下细针穿刺制作细胞块，利用细胞块进行诊断。非肿瘤性肿块采取保守治疗，囊肿及肿瘤采用手术治疗。将诊断为腺样囊性癌（ACC）和多形性腺瘤（PA）的肿块细胞块切片应用于干细胞因子受体CD117免疫细胞化学染色检测。
结果
标本满意率为95.1%（271/285）。诊断准确率为94.5%（256/271），灵敏度为87.0%（67/77），特异度为98.1%（157/160）。ACC中CD117阳性率为95.2%（20/21），而PA中为20.3%（25/123）。ACC中CD117阳性率高于PA（P<0.01）。
结论
超声引导下细针穿刺获取的细胞块联合分子标志物检测在腮腺肿块诊断中具有重要意义。
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