一种膦介导的2-对甲苯磺酰氨基查耳酮与MBH碳酸盐的串联环化反应过程，用于构建官能化氮杂苯并双环[4.3.0]衍生物。
A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo[4.3.0] derivatives.
作者信息
Zhang Qinglong, Zhu Yannan, Jin Hongxing, Huang You
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
出版信息
Chem Commun (Camb). 2017 Apr 4;53(28):3974-3977. doi: 10.1039/c6cc10155k.
A novel phosphine mediated sequential annulation process to construct functionalized aza-benzobicyclo[4.3.0] derivatives has been developed involving a one-pot sequential catalytic and stoichiometric process, which generates a series of benzobicyclo[4.3.0] compounds containing one quaternary center with up to 94% yield and 20 : 1 dr value. In this reaction, MBH carbonates act as 1,2,3-C synthons.
已开发出一种新型膦介导的构建官能化氮杂苯并双环[4.3.0]衍生物的串联环化过程，该过程涉及一锅串联催化和化学计量过程，可生成一系列含有一个季碳中心的苯并双环[4.3.0]化合物，产率高达94%，非对映选择性为20:1。在该反应中，MBH碳酸酯作为1,2,3-C合成子。
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