Norris H J, Bahr G F, Mikel U V
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000.
Anal Quant Cytol Histol. 1988 Feb;10(1):1-9.
The Feulgen DNA content and the nuclear measurements of four groups of intraductal proliferations of the breast (hyperplasia, atypical hyperplasia, well-differentiated carcinoma without cytologic atypia and intraductal carcinoma with cytologic atypia) were compared. Intraductal carcinoma with atypia was the only group distinct from the others on the basis of DNA content, nuclear area and perimeter. Although the other groups were separable from intraductal carcinoma with atypia, they could not be reliably distinguished from each other by any combination of measurements. At best, 69% of well-differentiated intraductal carcinomas could be distinguished from atypical hyperplasias using a combination of DNA content and nuclear perimeter measurements. Thus, the difficult distinction of atypical hyperplasia from well-differentiated intraductal carcinoma by light microscopy was not aided by DNA analysis or by nuclear measurements.
对四组乳腺导管内增殖病变（增生、非典型增生、无细胞学异型性的高分化癌和有细胞学异型性的导管内癌）的福尔根DNA含量及细胞核测量数据进行了比较。有异型性的导管内癌是唯一在DNA含量、核面积和周长方面与其他组不同的组。虽然其他组与有异型性的导管内癌可区分开，但通过任何测量组合都无法可靠地将它们彼此区分。使用DNA含量和核周长测量的组合，最多只能将69%的高分化导管内癌与非典型增生区分开来。因此，DNA分析或细胞核测量无助于通过光学显微镜将非典型增生与高分化导管内癌进行困难的区分。
