Rosser Andrew, Stover Cordula, Pareek Manish, Mukamolova Galina V
a Department of Infection, Immunity and Inflammation , University of Leicester , Leicester , UK.
b Department of Infection and Tropical Medicine , University Hospitals of Leicester NHS Trust , Leicester , UK.
Crit Rev Microbiol. 2017 Sep;43(5):621-630. doi: 10.1080/1040841X.2017.1283485. Epub 2017 Feb 17.
Resuscitation promoting factors (Rpf) are peptidoglycan-hydrolyzing enzymes that are pivotal in the resuscitation of quiescent actinobacteria including Mycobacterium tuberculosis. From the published data, it is clear that Rpf are required for the resuscitation of non-replicating bacilli and pathogenesis in murine infection model of tuberculosis, although their direct influence on human Mycobacterium tuberculosis infection is ill-defined. In this review, we describe the progress in the understanding of the roles that Rpf play in human tuberculosis pathogenesis and importance of bacilli dependent upon Rpf for growth for the outcome of human tuberculosis. We outline how this research is opening up important opportunities for the diagnosis, treatment and prevention of human disease, progress in which is essential to attain the ultimate goal of tuberculosis eradication.
复苏促进因子（Rpf）是肽聚糖水解酶，在包括结核分枝杆菌在内的静止放线菌的复苏中起关键作用。从已发表的数据来看，很明显Rpf是结核分枝杆菌在小鼠感染模型中复苏和发病所必需的，尽管它们对人类结核分枝杆菌感染的直接影响尚不明确。在本综述中，我们描述了在理解Rpf在人类结核病发病机制中的作用以及依赖Rpf生长的杆菌对人类结核病结局的重要性方面所取得的进展。我们概述了这项研究如何为人类疾病的诊断、治疗和预防开辟重要机遇，而这方面的进展对于实现根除结核病的最终目标至关重要。
