过渡金属、叠氮化物和氧化剂自由同型和异型偶联两性对甲苯磺酰腙到区域选择性三唑和吡唑。
Transition Metal, Azide, and Oxidant-Free Homo- and Heterocoupling of Ambiphilic Tosylhydrazones to the Regioselective Triazoles and Pyrazoles.
机构信息
Department of Chemistry, Indian Institute of Technology Guwahati , Assam 781039, India.
Organic Chemistry Division, CSIR-National Chemical Laboratory , Maharashtra-411008, India.
出版信息
Org Lett. 2017 Apr 7;19(7):1534-1537. doi: 10.1021/acs.orglett.7b00313. Epub 2017 Mar 24.
With N-tosylhydrazone as an ambiphilic reagent, an unprecedented cyclization reaction of two identical or different tosylhydrazones has been developed to access various 4,5-disubstituted-2H-triazoles under transition metal, azide, and oxidant-free conditions. A mechanistic rationalization study led to the identification of several electronically diverse unsaturated systems for regioselective synthesis of 1- and 2-substituted 1,2,3-triazoles and pyrazoles.
作为一种双亲试剂，N-对甲苯磺酰腙发展了一种前所未有的双同型或异型对甲苯磺酰腙环化反应，在无过渡金属、叠氮化物和氧化剂的条件下，可得到各种 4,5-二取代-2H-三唑。通过对反应机理的深入研究，确定了几种具有不同电子特性的不饱和体系，可实现 1-和 2-取代的 1,2,3-三唑和吡唑的区域选择性合成。
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