Yin Jun, Ni Bing, Tian Zhi-Qiang, Yang Fan, Liao Wei-Gong, Gao Yu-Qi
Department of Pathophysiology and High Altitude Pathology, Key Laboratory of High Altitude Environment Medicine, Ministry of Education, Key Laboratory of High Altitude Medicine, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, PR China.
Institute of Immunology, PLA, Third Military Medical University, Chongqing, PR China.
Biol Reprod. 2017 Mar 1;96(3):525-530. doi: 10.1095/biolreprod.116.144063.
Abnormal spermatogenesis is an important pathophysiological process underlying male infertility. Apoptosis of spermatogenic cells and disruption of ectoplasmic specialization (ES) have been characterized as the key biological events of this disorder. Under physiological and pathophysiological conditions (such as exposure to starvation, environmental chemicals, radiation), autophagy is activated in spermatogenic or Sertoli cells in order to maintain survival of the spermatogenic cells by inhibiting spermatogenic cell apoptosis and stabilizing the integrity of ES via degradation of PDZ and LIM domain 1 (PDLIM1), a negative regulator of cytoskeletal organization. Here, we review the most recent research progress towards understanding the pivotal effects of autophagy on spermatogenesis.
异常精子发生是男性不育的重要病理生理过程。生精细胞凋亡和外质特化（ES）破坏已被视为该疾病的关键生物学事件。在生理和病理生理条件下（如饥饿、接触环境化学物质、辐射），自噬在生精细胞或支持细胞中被激活，以通过抑制生精细胞凋亡和经由细胞骨架组织的负调节因子PDZ和LIM结构域1（PDLIM1）的降解来稳定ES的完整性，从而维持生精细胞的存活。在此，我们综述了关于理解自噬对精子发生的关键作用的最新研究进展。
