Shi Yu-Jie, Tsang Julia Y S, Ni Yun-Bi, Tse Gary M
Department of Pathology, Henan Province People's Hospital, Zhengzhou, Henan, China.
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Oncologist. 2017 Apr;22(4):487-490. doi: 10.1634/theoncologist.2016-0352. Epub 2017 Mar 24.
Intratumoral heterogeneity presents challenges in the management of cancer. To gain deeper insight in intratumoral heterogeneity at different levels and tumor sites for common biomarkers in breast cancers, this report examines seven cases of invasive breast cancer with multiple axillary nodal metastases and/or recurrences for immunohistochemical expression of estrogen receptors, progesterone receptors, human epidermal growth receptor 2, and Ki67 on all tissue blocks in both primary and metastatic tumors. 2017;22:487-490.
肿瘤内异质性给癌症治疗带来了挑战。为了更深入了解乳腺癌常见生物标志物在不同水平和肿瘤部位的肿瘤内异质性,本报告研究了7例伴有多枚腋窝淋巴结转移和/或复发的浸润性乳腺癌病例,检测其原发肿瘤和转移肿瘤所有组织块中雌激素受体、孕激素受体、人表皮生长因子受体2和Ki67的免疫组化表达情况。2017年;22:487 - 490。