[cGMP-dependent protein kinases: properties, regulation and biological role].

The data available in literature on properties, methods of regulation and biological role of cGMP-dependent protein kinases are analyzed and generalized. Evidence on distribution of these enzymes in different tissues and intracellular compartments is presented. Physicochemical properties of cGMP-dependent protein kinases from different sources are analyzed. Peculiarities of their primary structure, regulation of their activity at the expense of autophosphorylation as well as in the presence of the modulator protein, metal ions and other factors are considered. These data permit postulating importance of cGMP-dependent phosphorylation in some physiological and biochemical processes.