O'Neill Gavin, Ker Andrew, Mohammed Aslam, Karcher Anne Marie
Department of Orthopaedics, Southern General Hospital , Glasgow , UK.
Department of Microbiology, Aberdeen Royal Infirmary , Aberdeen , UK.
JMM Case Rep. 2016 Jun 10;3(3):e005030. doi: 10.1099/jmmcr.0.005030. eCollection 2016 Jun.
is currently a rarely reported pathogen. It has previously been associated with respiratory tract infections and bacteraemia in debilitated patients. However, under-reporting may occur due to misidentification by commonly used laboratory bacterial identification systems. This case is, to the best of our knowledge, the first reported case of osteomyelitis in the English language medical literature.
A 37-year-old male presented with a painful foot. He had no previous foot problems, history of injury or animal contact. Osteomyelitis was confirmed by magnetic resonance imaging (MRI), and blood cultures were positive for Gram-variable bacilli. The organism was identified initially as by the local routine diagnostic laboratory and as a species by the UK National Reference Laboratory (Colindale, London, UK), using standard operating procedures at the time. It was finally identified as an using 16S rRNA gene sequence analysis. Difficulties in the accurate identification of this organism remain current, as other biochemical identification systems have also resulted in misidentifications. The patient refused admission and intravenous antibiotics. He was successfully treated using an 8-week course of oral ciprofloxacin and amoxicillin based on antibiotic disc susceptibility testing resulting in clinical, serological and radiological resolution.
Laboratories should maintain a high index of suspicion for as several commonly used bacterial identification systems may not accurately identify the organism. Colonial morphology and absence of animal contact should prompt consideration of this organism in appropriate clinical situations. Oral ciprofloxacin and amoxicillin treatment was successful in this case.
目前是一种鲜有报道的病原体。它此前与体弱患者的呼吸道感染和菌血症有关。然而,由于常用实验室细菌鉴定系统的错误识别,可能存在漏报情况。据我们所知,本病例是英文医学文献中首次报道的骨髓炎病例。
一名37岁男性因足部疼痛就诊。他既往无足部问题、受伤史或动物接触史。磁共振成像(MRI)确诊为骨髓炎,血培养革兰氏可变杆菌阳性。当地常规诊断实验室最初将该菌鉴定为 ,英国国家参考实验室(英国伦敦科林代尔)当时按照标准操作程序将其鉴定为 属的一个菌种。最终通过16S rRNA基因序列分析确定为 。由于其他生化鉴定系统也出现过错误识别,目前准确鉴定该菌仍存在困难。患者拒绝住院和静脉使用抗生素。根据抗生素纸片药敏试验结果,给予患者为期8周的口服环丙沙星和阿莫西林治疗,取得了临床、血清学和影像学的治愈效果。
实验室应对 保持高度怀疑,因为几种常用的细菌鉴定系统可能无法准确鉴定该菌。在适当的临床情况下,菌落形态和无动物接触史应促使考虑该菌。本病例中口服环丙沙星和阿莫西林治疗成功。