• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

姜黄素激活CRABPII/RAR途径可诱导视黄酸介导的抗视黄酸乳腺癌细胞凋亡。

Activation of the CRABPII/RAR pathway by curcumin induces retinoic acid mediated apoptosis in retinoic acid resistant breast cancer cells.

作者信息

Thulasiraman Padmamalini, Garriga Galen, Danthuluri Veena, McAndrews Daniel J, Mohiuddin Imran Q

机构信息

Department of Biomedical Sciences, College of Allied Health, University of South Alabama, Mobile, AL 36688, USA.

出版信息

Oncol Rep. 2017 Apr;37(4):2007-2015. doi: 10.3892/or.2017.5495. Epub 2017 Mar 8.

DOI:10.3892/or.2017.5495
PMID:28350049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5367344/
Abstract

Due to the anti-proliferative and anti-apoptotic effects of retinoic acid (RA), this hormone has emerged as a target for several diseases, including cancer. However, development of retinoid resistance is a critical issue and efforts to understand the retinoid signaling pathway may identify useful biomarkers for future clinical trials. Apoptotic responses of RA are exhibited through the cellular RA-binding protein II (CRABPII)/retinoic acid receptor (RAR) signaling cascade. Delivery of RA to RAR by CRABPII enhances the transcriptional activity of genes involved in cell death and cell cycle arrest. The purpose of this study was to investigate the role of curcumin in sensitizing RA-resistant triple-negative breast cancer (TNBC) cells to RA-mediated apoptosis. We provide evidence that curcumin upregulates the expression of CRABPII, RARβ and RARγ in two different TNBC cell lines. Co-treatment of the cells with curcumin and RA results in increased apoptosis as demonstrated by elevated cleavage of poly(ADP-ribose) polymerase and cleaved caspase-9. Additionally, silencing CRABPII reverses curcumin sensitization of TNBC cells to the apoptotic inducing effects of RA. These findings provide mechanistic insights into sensitizing TNBC cells to RA-mediated cell death by curcumin-induced upregulation of the CRABPII/RAR pathway.

摘要

由于视黄酸（RA）具有抗增殖和抗凋亡作用，这种激素已成为包括癌症在内的多种疾病的治疗靶点。然而，类维生素A耐药性的产生是一个关键问题，了解类维生素A信号通路的研究可能会为未来的临床试验找到有用的生物标志物。RA的凋亡反应是通过细胞视黄酸结合蛋白II（CRABPII）/视黄酸受体（RAR）信号级联反应表现出来的。CRABPII将RA传递给RAR可增强参与细胞死亡和细胞周期阻滞的基因的转录活性。本研究的目的是探讨姜黄素在使RA耐药的三阴性乳腺癌（TNBC）细胞对RA介导的凋亡敏感化中的作用。我们提供的证据表明，姜黄素可上调两种不同TNBC细胞系中CRABPII、RARβ和RARγ的表达。姜黄素与RA联合处理细胞会导致凋亡增加，这可通过聚（ADP-核糖）聚合酶的切割增加和半胱天冬酶-9的切割来证明。此外，沉默CRABPII可逆转TNBC细胞对RA凋亡诱导作用的姜黄素致敏作用。这些发现为姜黄素诱导上调CRABPII/RAR通路使TNBC细胞对RA介导的细胞死亡敏感化提供了机制性见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/a39157330e65/OR-37-04-2007-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/5393af814277/OR-37-04-2007-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/dc3557e1ab9b/OR-37-04-2007-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/d77d1b366ca6/OR-37-04-2007-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/dafbd8b47506/OR-37-04-2007-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/a39157330e65/OR-37-04-2007-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/5393af814277/OR-37-04-2007-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/dc3557e1ab9b/OR-37-04-2007-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/d77d1b366ca6/OR-37-04-2007-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/dafbd8b47506/OR-37-04-2007-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2d3/5367344/a39157330e65/OR-37-04-2007-g04.jpg

相似文献

1
Activation of the CRABPII/RAR pathway by curcumin induces retinoic acid mediated apoptosis in retinoic acid resistant breast cancer cells.姜黄素激活CRABPII/RAR途径可诱导视黄酸介导的抗视黄酸乳腺癌细胞凋亡。
Oncol Rep. 2017 Apr;37(4):2007-2015. doi: 10.3892/or.2017.5495. Epub 2017 Mar 8.
2
Retinoic acid induction of human cellular retinoic acid-binding protein-II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid-responsive element with 5-base pair spacing.维甲酸诱导人细胞维甲酸结合蛋白-II基因转录是由维甲酸受体-类视黄醇X受体异二聚体介导的，该异二聚体与一个间隔5个碱基对的远上游维甲酸反应元件结合。
J Biol Chem. 1994 Sep 2;269(35):22334-9.
3
CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.细胞视黄酸结合蛋白1与乳腺癌的不良预后相关：这增加了乳腺癌细胞对视黄酸反应的复杂性。
Mol Cancer. 2015 Jul 5;14:129. doi: 10.1186/s12943-015-0380-7.
4
Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II.细胞周期蛋白D3是视黄酸受体的辅助因子，在细胞视黄酸结合蛋白II存在的情况下调节其活性。
J Biol Chem. 2003 Feb 21;278(8):6355-62. doi: 10.1074/jbc.M210697200. Epub 2002 Dec 12.
5
Suppression of mammary carcinoma cell growth by retinoic acid: the cell cycle control gene Btg2 is a direct target for retinoic acid receptor signaling.视黄酸对乳腺癌细胞生长的抑制作用：细胞周期调控基因Btg2是视黄酸受体信号传导的直接靶点。
Cancer Res. 2007 Jan 15;67(2):609-15. doi: 10.1158/0008-5472.CAN-06-0989.
6
The cellular retinoic acid binding protein II is a positive regulator of retinoic acid signaling in breast cancer cells.细胞视黄酸结合蛋白II是乳腺癌细胞中视黄酸信号通路的正向调节因子。
Cancer Res. 1997 May 1;57(9):1668-72.
7
Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling.视黄酸对乳腺癌生长的抑制作用：促凋亡基因是视黄酸受体和细胞视黄酸结合蛋白II信号通路的靶点。
Cancer Res. 2005 Sep 15;65(18):8193-9. doi: 10.1158/0008-5472.CAN-05-1177.
8
Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells.姜黄素可恢复三阴性乳腺癌细胞对维甲酸的敏感性。
BMC Cancer. 2014 Sep 27;14:724. doi: 10.1186/1471-2407-14-724.
9
Comparison of N-(4-hydroxyphenyl)retinamide and all-trans-retinoic acid in the regulation of retinoid receptor-mediated gene expression in human breast cancer cell lines.N-（4-羟苯基）视黄酰胺与全反式维甲酸对人乳腺癌细胞系中类视黄醇受体介导的基因表达调控的比较
Cancer Res. 1996 Mar 1;56(5):1056-62.
10
Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines.维甲酸（RA）与骨形态发生蛋白4（BMP - 4）凋亡信号在视网膜母细胞瘤细胞系中的累加效应
PLoS One. 2015 Jul 14;10(7):e0131467. doi: 10.1371/journal.pone.0131467. eCollection 2015.

引用本文的文献

1
Natural compounds targeting nuclear receptors for effective cancer therapy.靶向核受体的天然化合物在癌症治疗中的应用。
Cancer Metastasis Rev. 2023 Sep;42(3):765-822. doi: 10.1007/s10555-022-10068-w. Epub 2022 Dec 8.
2
Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives.乳腺癌治疗中植物化学物质的机制评估：当前认识与未来展望
RSC Adv. 2018 Aug 22;8(52):29714-29744. doi: 10.1039/c8ra04879g. eCollection 2018 Aug 20.
3
Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway.

本文引用的文献

1
Curcumin AntiCancer Studies in Pancreatic Cancer.姜黄素在胰腺癌中的抗癌研究。
Nutrients. 2016 Jul 16;8(7):433. doi: 10.3390/nu8070433.
2
Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells.姜黄素使水飞蓟素在结肠癌细胞中发挥协同抗癌活性。
J Cancer. 2016 Jun 23;7(10):1250-7. doi: 10.7150/jca.15690. eCollection 2016.
3
Curcumin in Treating Breast Cancer: A Review.姜黄素治疗乳腺癌的综述
小鼠 Latexin 缺乏通过 HECTD1/Rps3/NF-κB 通路上调炎症反应并加重结肠炎。
Sci Rep. 2020 Jun 17;10(1):9868. doi: 10.1038/s41598-020-66789-x.
4
Unraveling the Genomic-Epigenomic Interaction Landscape in Triple Negative and Non-Triple Negative Breast Cancer.解析三阴性和非三阴性乳腺癌中的基因组-表观基因组相互作用图谱
Cancers (Basel). 2020 Jun 12;12(6):1559. doi: 10.3390/cancers12061559.
5
Bottom up proteomics reveals novel differentiation proteins in neuroblastoma cells treated with 13-cis retinoic acid.从下到上的蛋白质组学揭示了用 13-顺式维甲酸处理的神经母细胞瘤细胞中的新型分化蛋白。
J Proteomics. 2019 Oct 30;209:103491. doi: 10.1016/j.jprot.2019.103491. Epub 2019 Aug 28.
6
Extrinsic or Intrinsic Apoptosis by Curcumin and Light: Still a Mystery.姜黄素和光诱导的细胞凋亡：仍然是一个谜。
Int J Mol Sci. 2019 Feb 19;20(4):905. doi: 10.3390/ijms20040905.
7
Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy.视黄醇在肿瘤学中的信号灯：视黄醇耐药性和敏感性的分子标志物及其在癌症分化治疗管理中的应用。
BMC Cancer. 2018 Nov 1;18(1):1059. doi: 10.1186/s12885-018-4966-5.
J Lab Autom. 2016 Dec;21(6):723-731. doi: 10.1177/2211068216655524. Epub 2016 Jun 20.
4
Decreased RARβ expression induces abundant inflammation and cervical precancerous lesions.视黄酸受体β（RARβ）表达降低会引发大量炎症和宫颈癌前病变。
Exp Cell Res. 2016 Aug 1;346(1):40-52. doi: 10.1016/j.yexcr.2016.05.010. Epub 2016 May 17.
5
Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway.姜黄素通过调节CXC趋化因子/核因子κB信号通路介导结直肠癌细胞系中奥沙利铂获得性耐药的逆转。
Sci Rep. 2016 Apr 19;6:24675. doi: 10.1038/srep24675.
6
Molecular mechanisms of curcumin and its semisynthetic analogues in prostate cancer prevention and treatment.姜黄素及其半合成类似物在前列腺癌预防和治疗中的分子机制
Life Sci. 2016 May 1;152:135-44. doi: 10.1016/j.lfs.2016.03.036. Epub 2016 Mar 24.
7
South Asian Medicinal Compounds as Modulators of Resistance to Chemotherapy and Radiotherapy.作为化疗和放疗抗性调节剂的南亚药用化合物
Cancers (Basel). 2016 Mar 5;8(3):32. doi: 10.3390/cancers8030032.
8
Loss of CRABP-II Characterizes Human Skin Poorly Differentiated Squamous Cell Carcinomas and Favors DMBA/TPA-Induced Carcinogenesis.CRABP-II的缺失是人类皮肤低分化鳞状细胞癌的特征，并促进二甲基苯并蒽/十四烷酰佛波醇乙酯诱导的致癌作用。
J Invest Dermatol. 2016 Jun;136(6):1255-1266. doi: 10.1016/j.jid.2016.01.039. Epub 2016 Mar 2.
9
Multi-Targeted Agents in Cancer Cell Chemosensitization: What We Learnt from Curcumin Thus Far.癌细胞化学增敏中的多靶点药物：我们目前从姜黄素中学到的知识。
Recent Pat Anticancer Drug Discov. 2016;11(1):67-97. doi: 10.2174/1574892810666151020101706.
10
Role of retinoids in the prevention and treatment of colorectal cancer.类视黄醇在结直肠癌预防和治疗中的作用。
World J Gastrointest Oncol. 2015 Oct 15;7(10):184-203. doi: 10.4251/wjgo.v7.i10.184.