代谢重编程在T细胞命运和功能中的作用。
The role of metabolic reprogramming in T cell fate and function.
作者信息
Patsoukis Nikolaos, Bardhan Kankana, Weaver Jessica, Herbel Christoph, Seth Pankaj, Li Lequn, Boussiotis Vassiliki A
机构信息
Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215; Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215.
Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215; Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
出版信息
Curr Trends Immunol. 2016;17:1-12.
T lymphocytes undergo extensive changes in their metabolic properties during their transition through various differentiation states, from naïve to effector to memory or regulatory roles. The cause and effect relationship between metabolism and differentiation is a field of intense investigation. Many recent studies demonstrate the dependency of T cell functional outcomes on metabolic pathways and the possibility of metabolic intervention to modify these functions. In this review, we describe the basic metabolic features of T cells and new findings on how these correlate with various differentiation fates and functions. We also highlight the latest information regarding the main factors that affect T cell metabolic reprogramming.
T淋巴细胞在从初始状态转变为效应状态、记忆状态或调节状态的各种分化过程中，其代谢特性会发生广泛变化。代谢与分化之间的因果关系是一个深入研究的领域。最近的许多研究表明，T细胞功能结果依赖于代谢途径，以及通过代谢干预来改变这些功能的可能性。在这篇综述中，我们描述了T细胞的基本代谢特征，以及关于这些特征如何与各种分化命运和功能相关的新发现。我们还强调了有关影响T细胞代谢重编程的主要因素的最新信息。
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