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非洲爪蟾早期发育过程中c-myc原癌基因的表达

Expression of c-myc proto-oncogene during the early development of Xenopus laevis.

作者信息

Nishikura K

机构信息

Wistar Institute, Philadelphia, Pennsylvania 19104.

出版信息

Oncogene Res. 1987 Jul;1(2):179-91.

PMID:2835732
Abstract

c-myc proto-oncogene expression in Xenopus laevis oocytes and developing embryos has been investigated. Stage VI oocytes as well as unfertilized eggs contain a high level of Xenopus c-myc mRNA (1-2.5 x 10(7) copies). However, this high level of maternal c-myc mRNA declines gradually during the time of rapid and synchronous cell cleavage and becomes almost undetectable after the mid-blastula transition. The zygotic genes then become activated for the first time, whereupon the amount of newly synthesized c-myc mRNA starts to increase again. The level of c-myc mRNA in the 1 day old embryo (stage 22) is comparable to that of oocyte or unfertilized egg. The finding suggest that c-myc gene products may play an important role during early embryogenesis, especially during the rapid synchronous cell cleavage period and onset of the mid-blastula transition.

摘要

已对非洲爪蟾卵母细胞和发育中的胚胎中的c-myc原癌基因表达进行了研究。VI期卵母细胞以及未受精卵含有高水平的非洲爪蟾c-myc mRNA(1-2.5×10⁷个拷贝)。然而,这种高水平的母源c-myc mRNA在快速同步细胞分裂期间逐渐下降,在囊胚中期转变后几乎检测不到。然后,合子基因首次被激活,随后新合成的c-myc mRNA量又开始增加。1日龄胚胎(22期)中的c-myc mRNA水平与卵母细胞或未受精卵的水平相当。这一发现表明,c-myc基因产物可能在早期胚胎发育过程中发挥重要作用,尤其是在快速同步细胞分裂期和囊胚中期转变开始时。

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