Villarejo-Zori Beatriz, Boya Patricia
Autophagy Lab, Department of Cellular and Molecular Biology, Centro de investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Espagne.
Med Sci (Paris). 2017 Mar;33(3):297-304. doi: 10.1051/medsci/20173303017. Epub 2017 Apr 3.
The retina is a light-sensitive tissue in the vertebrate eye that detects and processes visual images. The eye, including retina, is exposed to a variety of environmental insults and stressors, among which genetic mutations and age-associated alterations that impair their function. Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular components under basal and stress conditions. Proteins, lipids, and even whole organelles are engulfed in autophagosomes and delivered to the lysosome for elimination. Research has only begun to examine the role of autophagy in the visual system. Here, we review the main studies that have sought to explain autophagy's importance for visual function.
视网膜是脊椎动物眼中的一种光敏感组织,用于检测和处理视觉图像。眼睛,包括视网膜,会受到各种环境损伤和应激源的影响,其中基因突变和与年龄相关的改变会损害它们的功能。自噬是一种分解代谢途径,在基础和应激条件下促进细胞成分的降解和循环利用。蛋白质、脂质,甚至整个细胞器都会被吞噬进自噬体,然后被运送到溶酶体进行清除。关于自噬在视觉系统中的作用的研究才刚刚开始。在这里,我们回顾了一些主要研究,这些研究试图解释自噬对视觉功能的重要性。