Cucchiarini Magali
Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr, Bldg 37, D-66421 Homburg/Saar, Germany.
Biomed Mater Eng. 2017;28(s1):S201-S207. doi: 10.3233/BME-171642.
Articular cartilage injuries have an inadequate aptitude to reproduce the original structure and functions of this highly specialized tissue. As most of the currently available options also do not lead to the restoration of the original hyaline cartilage, novel treatments are critically needed to address this global problems in the clinics. Gene therapy combined with tissue engineering approaches offers effective tools capable of enhancing cartilage repair experimentally, especially those based on the controlled delivery of the highly effective, clinically adapted recombinant adeno-associated viral (rAAV) vectors. This work presents an overview of the most recent evidence showing the benefits of using rAAV vectors and biocompatible materials for the elaboration of adapted treatments against cartilage injuries.
关节软骨损伤难以重现这种高度专业化组织的原始结构和功能。由于目前大多数可用的治疗方法也无法恢复原始透明软骨，临床上迫切需要新的治疗方法来解决这一全球性问题。基因治疗与组织工程方法相结合提供了有效的工具，能够在实验中增强软骨修复，特别是那些基于高效、临床适用的重组腺相关病毒（rAAV）载体的可控递送的方法。本文概述了最新证据，这些证据表明使用rAAV载体和生物相容性材料来制定针对软骨损伤的适应性治疗方法的益处。
