He Hai-Yan, Liu Mou-Ze, Zhang Yue-Li, Zhang Wei
International Medical Department, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China; National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Genomics Proteomics Bioinformatics. 2017 Apr;15(2):94-100. doi: 10.1016/j.gpb.2016.10.005. Epub 2017 Apr 1.
Vitamins are vital to sustain normal physiological function, metabolism, and growth for all living organisms. Being an integral component of coenzyme, vitamins can affect the catalytic activities of many enzymes and the expression of drug transporters. Genetic variations in metabolism and/or transporter genes of drugs can influence the exposure of the human body to drugs and/or their active metabolites, thus contributing to the variations in drug responses and toxicities. Nonetheless, pharmacogenomics studies on nutrients have been rarely summarized. In this article, we reviewed recent progress on vitamin pharmacogenomics, for a better understanding on the influence of vitamin-related gene polymorphisms on inter-individual differences in diseases and drug efficacy and safety.
维生素对于维持所有生物体的正常生理功能、新陈代谢和生长至关重要。作为辅酶的一个组成部分，维生素可以影响许多酶的催化活性以及药物转运体的表达。药物代谢和/或转运体基因的遗传变异会影响人体对药物和/或其活性代谢产物的暴露，从而导致药物反应和毒性的差异。尽管如此，关于营养素的药物基因组学研究很少被总结。在本文中，我们综述了维生素药物基因组学的最新进展，以便更好地理解维生素相关基因多态性对疾病个体差异以及药物疗效和安全性的影响。
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