Herlihy Sarah E, Lin Cindy, Nefedova Yulia
Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce Street, Room 376, Philadelphia, PA, 19104, USA.
Cancer Immunol Immunother. 2017 Aug;66(8):1007-1014. doi: 10.1007/s00262-017-1992-0. Epub 2017 Apr 4.
Survival, growth, and response to chemotherapy of cancer cells depends strongly on the interaction of cancer cells with the tumor microenvironment. In multiple myeloma, a cancer of plasma cells that localizes preferentially in the bone marrow, the microenvironment is highly enriched with myeloid cells. The majority of myeloid cells are represented by mature and immature neutrophils. The contribution of the different myeloid cell populations to tumor progression and chemoresistance in multiple myeloma is discussed.
癌细胞的存活、生长以及对化疗的反应在很大程度上取决于癌细胞与肿瘤微环境的相互作用。在多发性骨髓瘤(一种优先定位于骨髓的浆细胞癌)中,微环境中富含髓样细胞。大多数髓样细胞由成熟和未成熟的中性粒细胞组成。本文讨论了不同髓样细胞群体在多发性骨髓瘤肿瘤进展和化疗耐药中的作用。