Arch Pathol Lab Med. 1988 Jul;112(7):673-720.
Silicosis, a disease of historical importance, continues to occur cryptically today. Its pathogenesis is under ongoing study as new concepts of pathobiology evolve. In this article, the gross and microscopic features of the disease in the lungs and the lesions in lymph nodes and other viscera are described. These tissue changes are then discussed in the context of clinical disease and other possible or established complications of silica exposure (ie, scleroderma and rheumatoid arthritis, glomerulonephritis, and bronchogenic carcinoma). Silicates are members of a large family of common minerals, some of which have commercial importance. Silicates are less fibrogenic than silica when inhaled into the lungs, but cause characteristic lesions after heavy prolonged exposure. The features of these disease conditions are described herein. Various aspects of the mineralogy and tissue diagnosis of silicosis and lung disease due to silicates are reviewed. An overview of contemporary regulatory considerations is provided.
矽肺是一种具有历史重要性的疾病，如今仍在悄然发生。随着病理生物学新概念的发展，其发病机制正在持续研究中。在本文中，描述了该疾病在肺部的大体和微观特征以及淋巴结和其他内脏的病变。然后结合临床疾病以及二氧化硅暴露的其他可能或已确定的并发症（即硬皮病和类风湿性关节炎、肾小球肾炎和支气管源性癌）来讨论这些组织变化。硅酸盐是一大类常见矿物中的成员，其中一些具有商业重要性。吸入肺部时，硅酸盐的致纤维化作用比二氧化硅小，但在长期大量接触后会引起特征性病变。本文描述了这些疾病状况的特征。综述了矽肺和硅酸盐所致肺部疾病的矿物学和组织诊断的各个方面。还提供了当代监管考量的概述。
