环磷酸腺苷（cAMP）对大鼠肾脏中α1-肾上腺素能受体刺激引起的磷酸肌醇反应的抑制作用。
Inhibition by cAMP of the phosphoinositide response to alpha 1-adrenoceptor stimulation in rat kidney.
作者信息
Neylon C B, Summers R J
机构信息
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Eur J Pharmacol. 1988 Apr 13;148(3):441-4. doi: 10.1016/0014-2999(88)90124-0.
The effect of increasing intracellular levels of cAMP has been investigated on the PI response to stimulation of alpha 1-adrenoceptors in rat kidney. Stimulation of adenylate cyclase with forskolin or incubation with dibutyryl cAMP (dcAMP) inhibited noradrenaline (NA)-stimulated [3H]inositol phosphate (IP) accumulation. Forskolin did not alter the EC50 to NA. No effect on NA-stimulated [3H]IP accumulation was seen with dibutyryl cGMP (dcGMP). The results suggest that hormones which produce alterations in cAMP levels influence alpha 1-adrenoceptor-mediated responses.
已经研究了细胞内cAMP水平升高对大鼠肾脏中α1-肾上腺素能受体刺激的磷脂酰肌醇（PI）反应的影响。用福斯可林刺激腺苷酸环化酶或用二丁酰cAMP（dcAMP）孵育可抑制去甲肾上腺素（NA）刺激的[3H]肌醇磷酸（IP）积累。福斯可林不会改变NA的半数有效浓度（EC50）。二丁酰cGMP（dcGMP）对NA刺激的[3H]IP积累没有影响。结果表明，引起cAMP水平改变的激素会影响α1-肾上腺素能受体介导的反应。
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