孕前体重指数较高是玛雅-梅斯蒂索妇女发生子痫前期的危险因素：一项队列研究。

Higher prepregnancy body mass index is a risk factor for developing preeclampsia in Maya-Mestizo women: a cohort study.

机构信息

a Laboratorio de Biología de la Reproducción , Centro de Investigaciones Regionales "Dr. Hideyo NoguchiUniversidad Autónoma de Yucatán" , Mérida , México.

b Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina , Instituto Politécnico Nacional , México , D.F. , México.

出版信息

Ethn Health. 2018 Aug;23(6):682-690. doi: 10.1080/13557858.2017.1315367. Epub 2017 Apr 6.

DOI:10.1080/13557858.2017.1315367

PMID:28385076

Abstract

AIM

Preeclampsia and obesity are two closely related syndromes. The high maternal prepregnancy body mass index (BMI) is a risk factor for present preeclampsia, independently of the ethnic background of the studied population. The aim of this study was to analyse in a prospective cohort study the relation between prepregnancy BMI and development of preeclampsia in Maya-Mestizo women.

DESIGN

This is a prospective cohort study of 642 pregnant women that were included in the first trimester of the pregnancy (gestational age ≤12 weeks at the first antenatal visit) and all of them were of Maya-Mestizo ethnic origin from the state of Yucatán, México. We assessed the potential risk factors for preeclampsia and documented the prepregnancy BMI (kg/m) that was based on measured height and maternal self-report of prepregnancy weight at the initial visit. Besides, in the antenatal visit we documented if the pregnant women developed preeclampsia.

RESULTS

Of the 642 pregnant Maya-Mestizo women, 49 developed preeclampsia, with an incidence of 7.6% (44.9% had severe and 55% mild). The prepregnancy BMI was higher in women with developed preeclampsia than in those with normal pregnancies. Women with overweight or obesity in comparison with normal weight presented a RR = 2.82 (95% CI: 1.32-6.03; P = 0.008) and RR= 4.22 (95% CI: 2.07-8.61; P = 0.001), respectively.

CONCLUSIONS

Our findings expand the previous studies to show that the higher prepregnancy BMI is a strong, independent risk factor for preeclampsia.

摘要

目的

子痫前期和肥胖是两种密切相关的综合征。孕妇孕前体质量指数（BMI）较高是目前子痫前期的一个危险因素，而与研究人群的种族背景无关。本研究旨在分析在一个前瞻性队列研究中，玛雅-梅斯蒂索人孕妇的孕前 BMI 与子痫前期的发展之间的关系。

设计

这是一项对 642 名孕妇的前瞻性队列研究，这些孕妇在妊娠早期（第一次产前检查时的孕龄≤12 周）被纳入研究，并且全部为来自墨西哥尤卡坦州的玛雅-梅斯蒂索人。我们评估了子痫前期的潜在危险因素，并记录了孕前 BMI（kg/m），这是基于测量的身高和孕妇在首次就诊时报告的孕前体重。此外，在产前检查中，我们记录了孕妇是否发生子痫前期。

结果

在 642 名怀孕的玛雅-梅斯蒂索妇女中，有 49 人发生了子痫前期，发病率为 7.6%（44.9%为重度，55%为轻度）。与正常妊娠的孕妇相比，发生子痫前期的孕妇的孕前 BMI 更高。与正常体重的孕妇相比，超重或肥胖的孕妇发生子痫前期的 RR=2.82（95%CI：1.32-6.03；P=0.008）和 RR=4.22（95%CI：2.07-8.61；P=0.001）。