Zhao X, Robinson P A
School of Physics, The University of Sydney, Sydney, New South Wales, 2006, Australia.
Center for Integrative Brain Function, University of Sydney, NSW, 2006, Australia.
J Comput Neurosci. 2017 Jun;42(3):307-321. doi: 10.1007/s10827-017-0642-z. Epub 2017 Apr 7.
Epileptiform discharges on an isolated cortex are explored using neural field theory. A neural field model of the isolated cortex is used that consists of three neural populations, excitatory, inhibitory, and excitatory bursting. Mechanisms by which an isolated cortex gives rise to seizure-like waveforms thought to underly pathological EEG waveforms on the deafferented cortex are explored. It is shown that the model reproduces similar time series and oscillatory frequencies for paroxysmal discharges when compared with physiological recordings both during acute and chronic deafferentation states. Furthermore, within our model ictal activity arises from perturbations to steady-states very close to the dynamical system's instability boundary; hence, these are distinct from corticothalamic seizures observed in the model for the intact brain which involved limit-cycle dynamics. The results are applied to experiments in deafferented cats.
利用神经场理论对孤立皮层上的癫痫样放电进行了研究。使用了一个孤立皮层的神经场模型，该模型由三个神经群体组成，即兴奋性、抑制性和兴奋性爆发性群体。探讨了孤立皮层产生被认为是去传入皮层病理性脑电图波形基础的癫痫样波形的机制。结果表明，与急性和慢性去传入状态下的生理记录相比，该模型在阵发性放电时再现了相似的时间序列和振荡频率。此外，在我们的模型中，发作期活动源于对非常接近动态系统不稳定边界的稳态的扰动；因此，这些与在完整大脑模型中观察到的涉及极限环动力学的皮质丘脑癫痫不同。这些结果被应用于去传入猫的实验中。
