Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University , Beijing 100871, China.
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School , Shenzhen 518055, China.
J Am Chem Soc. 2017 Apr 26;139(16):5732-5735. doi: 10.1021/jacs.7b02561. Epub 2017 Apr 14.
Asymmetric total synthesis of structurally intriguing and highly oxygenated lancifodilactone G acetate (7) has been achieved for the first time in 28 steps from a cheap commodity chemical, 2-(triisopropylsiloxy)-1,3-butadiene.
首次以廉价商品化学物质 2-(三异丙基硅氧基)-1,3-丁二烯为原料，通过 28 步反应，实现了结构独特、高度含氧的 lancifodilactone G 乙酸酯（7）的不对称全合成。
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