Chang Han-Wen, Studitsky Vasily M
Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Biology Faculty, Lomonosov Moscow State University; Moscow, Russia.
J Nat Sci. 2017 Feb;3(2).
Efficient overcoming of the nucleosomal barrier and accurate maintenance of associated histone marks during chromatin replication are essential for normal functioning of the cell. Recent studies revealed new protein factors and histone modifications contributing to overcoming the nucleosomal barrier, and suggested an important role for DNA looping in survival of the original histones during replication. These studies suggest new possible mechanisms for transmitting the histone code to next generations of cells.
在染色质复制过程中高效克服核小体屏障并准确维持相关组蛋白标记对于细胞的正常功能至关重要。最近的研究揭示了有助于克服核小体屏障的新蛋白质因子和组蛋白修饰,并表明DNA环化在复制过程中原代组蛋白存活中发挥重要作用。这些研究提出了将组蛋白密码传递给下一代细胞的新可能机制。