Division of Geriatric Medicine, Department of Medicine, University of Alberta, 1-198 Clinical Sciences Building, 11350-11383 Avenue, Edmonton, Alberta T6G 2P4, Canada.
Nat Rev Urol. 2017 Jul;14(7):440-448. doi: 10.1038/nrurol.2017.53. Epub 2017 Apr 11.
The prevalence of urinary incontinence and other lower urinary tract symptoms (LUTS) increases in association with increasing age. This effect is more noticeable in men after the seventh decade of life and, in women, postmenopausally. However, the changes in the lower urinary tract, peripheral nervous system and central nervous system that underpin this observation are both multifactorial and inadequately understood; much debate exists regarding whether these observed changes are pathological or are a part of the 'normal' ageing process; with both health professionals and older people often holding the view that incontinence is an expected part of normal ageing. Here we aim to summarize the current level of knowledge regarding the physiological and hormonal changes that take place during the ageing process and discuss whether the occurrence of urinary incontinence or other LUTS in later life better reflect part of the 'normal' ageing process or the presence of unaddressed pathology.
尿失禁和其他下尿路症状(LUTS)的患病率随着年龄的增长而增加。这种影响在男性中更为明显,在 70 岁以后,而在女性中,绝经后更为明显。然而,支持这一观察结果的下尿路、周围神经系统和中枢神经系统的变化是多因素的,并且还不够了解;关于这些观察到的变化是病理性的还是“正常”衰老过程的一部分存在很多争论;卫生专业人员和老年人通常都认为失禁是正常衰老的一部分。在这里,我们旨在总结目前关于衰老过程中发生的生理和激素变化的知识水平,并讨论晚年发生尿失禁或其他 LUTS 是更好地反映“正常”衰老过程的一部分还是存在未解决的病理问题。