Wallace M N
Institute of Anatomy B (Neurobiology), University of Aarhus, Denmark.
Neuroscience. 1988 May;25(2):569-83. doi: 10.1016/0306-4522(88)90259-x.
A lattice of high oxidative metabolic activity occurs in the intermediate gray layer of the human, monkey, and cat superior colliculus. It is composed of a matrix of high enzyme activity that surrounds pale islands or bands of lower activity. In the human the pale bands are 300-400 micron wide while in the smaller colliculi of the monkey and cat they are 100-200 micron wide. The lattice was demonstrated by studying either cytochrome oxidase or succinate dehydrogenase. In the cat and monkey the lattice occurs at the same depth as the lattice of intense acetylcholinesterase activity, but the two lattices are not in spatial register. In the human the lattice of high oxidative metabolic activity is in the middle of the intermediate gray layer, whereas the lattice of intensely stained cholinesterase activity is at the base of this layer, but again the two lattices are not in spatial register. However, in the middle of the intermediate gray layer of the human, there are elongated islands and bands of very low acetylcholinesterase activity that coincide with the pale islands and bands of low cytochrome oxidase activity. An additional lattice of high enzyme activity occurs based on the enzyme nicotinamide dinucleotide phosphate (reduced form)-diaphorase. This lattice is prominent in the cat, occurs more faintly in the monkey, but did not appear to be present in the human. In the intermediate gray layer it had a high degree of overlap with the acetylcholinesterase lattice. The lattice of high oxidative metabolism contains loosely knit clusters of large multipolar cells containing high cytochrome oxidase activity and these cells do not occur in the pale islands. By contrast the cell bodies in the intermediate gray layer that contain either acetylcholinesterase or the diaphorase occur both between and within the patches of corresponding, high enzyme activity. It is suggested that the acetylcholinesterase and diaphorase lattices are mainly associated with afferent fibers while the lattice of high oxidative metabolism is mainly associated with intrinsic cells. The lattices occur in all mammals studied to date and appear to represent a fundamental principle in the organization of the mammalian colliculus. It is concluded that the lattices will provide a useful basis for further studies of the relationship between the many afferent and efferent modules thought to exist in this structure.
在人类、猴子和猫的上丘中间灰质层中出现了一个具有高氧化代谢活性的格状结构。它由高酶活性的基质组成，该基质围绕着浅色的低活性岛或带。在人类中，浅色带宽300 - 400微米，而在猴子和猫较小的上丘中，它们宽100 - 200微米。通过研究细胞色素氧化酶或琥珀酸脱氢酶证实了这种格状结构。在猫和猴子中，这种格状结构出现在与强烈乙酰胆碱酯酶活性格状结构相同的深度，但这两种格状结构在空间上并不对齐。在人类中，高氧化代谢活性的格状结构位于中间灰质层的中部，而强烈染色的胆碱酯酶活性格状结构位于该层的底部，但同样这两种格状结构在空间上也不对齐。然而，在人类中间灰质层的中部，存在与低细胞色素氧化酶活性的浅色岛和带重合的、乙酰胆碱酯酶活性非常低的细长岛和带。基于烟酰胺腺嘌呤二核苷酸磷酸（还原型） - 黄递酶还出现了另一个高酶活性的格状结构。这种格状结构在猫中很突出，在猴子中较淡，但在人类中似乎不存在。在中间灰质层中，它与乙酰胆碱酯酶格状结构有高度重叠。高氧化代谢的格状结构包含具有高细胞色素氧化酶活性的大型多极细胞的松散簇，而这些细胞在浅色岛中不存在。相比之下，中间灰质层中含有乙酰胆碱酯酶或黄递酶的细胞体既出现在相应高酶活性区域之间，也出现在这些区域内部。有人认为，乙酰胆碱酯酶和黄递酶格状结构主要与传入纤维相关，而高氧化代谢格状结构主要与内在细胞相关。这种格状结构在迄今研究的所有哺乳动物中都存在，似乎代表了哺乳动物上丘组织的一个基本原理。得出的结论是，这些格状结构将为进一步研究该结构中许多被认为存在的传入和传出模块之间的关系提供有用的基础。
