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间歇导尿对伴有神经源性尿失禁的脊髓损伤患者生活质量调整年数(QALYs)的影响。

Impact of clean intermittent catheterization on quality adjusted life years (QALYs) in spinal cord injury patients with neurogenic urinary incontinence.

机构信息

Department of Urology, Jessenius Faculty of Medicine, Comenius University Bratislava, Martin, Slovak Republic.

Department of Urology, University Hospital, Ostrava, Czech Republic.

出版信息

Neurourol Urodyn. 2018 Jan;37(1):250-256. doi: 10.1002/nau.23283. Epub 2017 Apr 13.

DOI:10.1002/nau.23283
PMID:28407301
Abstract

AIMS

The impact of clean intermittent catheterization (CIC) on quality adjusted life years (QALYs) gained in adults' spinal cord injury population with neurogenic urinary incontinence (UI).

METHODS

Patients were recruited from the national registry January-June 2014. The inclusion criteria were adults, neurogenic UI due to spinal cord injury (SCI), use of collection devices and CIC for more than 6 months. The exclusion criteria were inability to perform CIC, cancer of the lower urinary tract and fistulas formation. Measurement tools were the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) and an estimation of life expectancy by the national registry. The calculation of the weighting factor (WF) was obtained by linear transformation of the ICIQ-UI SF total score. A score was transformed to the range from 0 (worst impact) to 1 (no impact). The QALYs was calculated as the weighting factor × life expectancy in years.

RESULTS

A total of 229/365 patients were involved in this study (63%). Patients before CIC reached an ICIQ mean score of 14.83, WF of 0.29, and QALYs of 9.02 during life expectancy. After 6 months of follow-up using CIC, ICIQ reached 9.12, WF 0.57 and QALYs 17.45. The number of QALYs increased by 93.5% and UI evaluated with the ICIQ-UI SF decreased by 38.5% (P < 0.01).

CONCLUSIONS

The CIC of the urinary bladder statistically significantly increased the number of QALYs and reduced the degree of UI in SCI patients.

摘要

目的

探讨清洁间歇性导尿(CIC)对伴有神经源性尿失禁(UI)的脊髓损伤成人患者获得的质量调整生命年(QALYs)的影响。

方法

患者于 2014 年 1 月至 6 月从国家登记处招募。纳入标准为成年人、脊髓损伤(SCI)引起的神经源性 UI、使用收集装置和 CIC 超过 6 个月。排除标准为无法进行 CIC、下尿路癌症和瘘管形成。测量工具为国际尿失禁咨询问卷-尿失禁简短表(ICIQ-UI SF)和国家登记处估计的预期寿命。权重因子(WF)的计算通过 ICIQ-UI SF 总分的线性变换获得。得分转换为 0(影响最差)至 1(无影响)的范围。QALYs 计算为权重因子×预期寿命(年)。

结果

共有 229/365 名患者(63%)参与了本研究。在进行 CIC 之前,患者的 ICIQ 平均得分为 14.83,WF 为 0.29,预期寿命内的 QALYs 为 9.02。在进行 6 个月的 CIC 随访后,ICIQ 达到 9.12,WF 为 0.57,QALYs 为 17.45。QALYs 增加了 93.5%,ICIQ-UI SF 评估的 UI 减少了 38.5%(P<0.01)。

结论

CIC 膀胱统计学上显著增加了 SCI 患者的 QALYs 数量,并降低了 UI 的严重程度。

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