Tamura Masato, Nemoto Eiji
Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, N13, W7, Sapporo, Japan.
Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba, Sendai, Japan.
Jpn Dent Sci Rev. 2016 Nov;52(4):75-83. doi: 10.1016/j.jdsr.2016.04.001. Epub 2016 May 5.
Wnt signaling plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnt ligands, receptors, transducers, transcription factors, and antagonists have been identified in mammals. Two distinct Wnt signaling pathways, the canonical signaling pathway and the noncanonical signaling pathway, have been described. Some Wnt signaling pathway components are expressed in the dental epithelium and mesenchyme during tooth development in humans and mice. Functional studies and experimental analysis of relevant animal models confirm the effects of Wnt signaling pathway on the regulation of developing tooth formation and adult tooth homeostasis. Mutations in some Wnt signaling pathway components have been identified in syndromic and non-syndromic tooth agenesis. This review provides an overview of progress in elucidating the role of Wnt signaling pathway components in the tooth and the resulting possibilities for therapeutic development.
Wnt信号通路在胚胎发育和成年期稳态的许多过程中发挥着核心作用。在哺乳动物中已鉴定出至少19种类型的Wnt配体、受体、转导子、转录因子和拮抗剂。已描述了两种不同的Wnt信号通路，即经典信号通路和非经典信号通路。在人类和小鼠牙齿发育过程中，一些Wnt信号通路成分在牙上皮和间充质中表达。相关动物模型的功能研究和实验分析证实了Wnt信号通路对发育中牙齿形成和成年牙齿稳态调节的作用。在综合征性和非综合征性牙齿发育不全中已鉴定出一些Wnt信号通路成分的突变。本综述概述了阐明Wnt信号通路成分在牙齿中的作用方面的进展以及由此产生的治疗开发可能性。
