超越相关性、敏感性和特异性：肿瘤学临床试验及癌症治疗中高级成像评估的案例示例
Beyond Correlations, Sensitivities, and Specificities: Case Examples of the Evaluation of Advanced Imaging in Oncology Clinical Trials and Cancer Treatment.
作者信息
Lin Frank I, Huang Erich P, Shankar Lalitha K
机构信息
Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD 20892.
Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.
出版信息
Acad Radiol. 2017 Aug;24(8):1027-1035. doi: 10.1016/j.acra.2016.11.024. Epub 2017 Apr 11.
Although advanced imaging is an important component of oncology clinical trials, there has not been a lot of success in advancing its use from a research perspective. One likely reason is the lack of consensus on the methodology used to study advanced imaging in trials, which results in a disconcerted research effort and produces data that are difficult to collate for use in validating the imaging components being studied. Imaging is used in cancer clinical trials for various indications, and the study design needed to evaluate the imaging in a particular indication will vary. Through case examples, this paper will discuss how advanced imaging is currently being investigated in oncology clinical trials, categorized by the potential clinical indication for the imaging tool and offer suggestions on how development should proceed to further evaluate imaging in the given indication. Available National Cancer Institute resources that can assist in this process will also be discussed.
尽管先进成像技术是肿瘤学临床试验的重要组成部分，但从研究角度推进其应用方面尚未取得很大成功。一个可能的原因是在试验中用于研究先进成像技术的方法缺乏共识，这导致研究工作不协调，并产生难以整理用于验证所研究成像组件的数据。成像技术在癌症临床试验中有多种应用指征，评估特定指征成像所需的研究设计会有所不同。通过案例，本文将讨论目前在肿瘤学临床试验中如何研究先进成像技术，按成像工具的潜在临床指征进行分类，并就如何推进开发以在给定指征中进一步评估成像技术提供建议。还将讨论可协助这一过程的美国国家癌症研究所现有资源。
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