Gunther R, Felice L J, Nelson R K, Franson A M
Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis 55455.
J Am Vet Med Assoc. 1988 Jul 15;193(2):211-4.
As a follow-up to an investigation of 2 dogs that died as a result of apparent toxicosis attributable to a cholecalciferol-containing rodenticide, we tested the toxicity of this product in dogs. Two groups of 2 dogs each were fed amounts of rodenticide that provided 20 and 10 mg of cholecalciferol/kg of body weight (approx one fourth and one eighth of the published LD50, respectively). All dogs developed hypercalcemia and hyperphosphatemia and then died. Major lesions were gastrointestinal hemorrhage, myocardial necrosis, and mineralization of vascular walls. Our data indicate that cholecalciferol-containing rodenticides pose a much greater hazard to dogs than was previously believed.
作为对2只因明显的含胆钙化醇灭鼠剂中毒死亡的犬进行调查的后续研究，我们对该产品在犬中的毒性进行了测试。将两组犬，每组2只，分别喂食能提供20和10 mg胆钙化醇/千克体重的灭鼠剂（分别约为已公布半数致死量的四分之一和八分之一）。所有犬均出现高钙血症和高磷血症，随后死亡。主要病变为胃肠道出血、心肌坏死和血管壁矿化。我们的数据表明，含胆钙化醇的灭鼠剂对犬构成的危害比之前认为的要大得多。
