中国荷斯坦牛Toll样受体2基因多态性及其与牛结核病的关联
Toll-like receptor 2 gene polymorphisms in Chinese Holstein cattle and their associations with bovine tuberculosis.
作者信息
Zhao Zhanqin, Xue Yun, Hu Zhigang, Zhou Feng, Ma Beibei, Long Ta, Xue Qiao, Liu Huisheng
机构信息
Lab of Veterinary Microbiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China; Lab of Medical Engineering, College of Medical Technology and Engineering, Henan University of Science and Technology, No. 31 Anhui Road, Luoyang 471003, China.
Lab of Medical Engineering, College of Medical Technology and Engineering, Henan University of Science and Technology, No. 31 Anhui Road, Luoyang 471003, China.
出版信息
Vet Immunol Immunopathol. 2017 Apr;186:51-54. doi: 10.1016/j.vetimm.2017.02.007. Epub 2017 Feb 28.
This study evaluated whether there was an association between polymorphisms within the Toll-like receptor 2 gene (TLR2) of Chinese Holstein cattle and susceptibility to bovine tuberculosis (BTB). In a case-control study including 210 BTB cases and 237 control cattle, we found only two common single-nucleotide polymorphisms (SNPs) within the entire coding region of the TLR2 gene, A631G (rs95214857) and T1707C (rs1388116488). Additionally, the allele and genotype distributions of A631G and T1707C were not different between case and control groups, indicated that these SNPs were not associated with susceptibility to BTB. These results suggested that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle.
本研究评估了中国荷斯坦牛Toll样受体2基因（TLR2）内的多态性与牛结核病（BTB）易感性之间是否存在关联。在一项包括210例BTB病例和237头对照牛的病例对照研究中，我们在TLR2基因的整个编码区域仅发现了两个常见的单核苷酸多态性（SNP），即A631G（rs95214857）和T1707C（rs1388116488）。此外，病例组和对照组之间A631G和T1707C的等位基因和基因型分布没有差异，表明这些SNP与BTB易感性无关。这些结果表明，TLR2基因多态性可能在中国荷斯坦牛的BTB风险中不发挥重要作用。
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