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用锝-99m HM-PAO进行局部脑血流量定量测量：使用多放射性核素数字定量放射自显影术进行评估。

Quantitative local cerebral blood flow measurements with technetium-99m HM-PAO: evaluation using multiple radionuclide digital quantitative autoradiography.

作者信息

Lear J L

机构信息

Department of Radiology, University of Colorado Health Sciences Center.

出版信息

J Nucl Med. 1988 Aug;29(8):1387-92.

PMID:2841432
Abstract

We investigated d,1 [99mTc]hexamethylpropyleneamine oxime complex (HM-PAO) as a tracer for quantitative measurement of local cerebral blood flow (LCBF) in a series of awake male rats. LCBF measurements with HM-PAO were compared to those of two other tracers, [14C] iodoantipyrine (IAP) and [201Tl]diethyldithiocarbamate (DDC), using quantitative double and triple tracer digital autoradiography. LCBF values with HM-PAO averaged 64% those of IAP and were generally linearly related. Detailed analysis suggested that the underestimation of LCBF by HM-PAO was related to blood constituent binding and/or rapid conversion to a noncerebrophilic compound, as well as noninstantaneous cerebral trapping, rather than to diffusion limitation.

摘要

我们在一系列清醒雄性大鼠中研究了消旋[99mTc]六甲基丙烯胺肟复合物（HM-PAO）作为定量测量局部脑血流量（LCBF）的示踪剂。使用定量双示踪剂和三示踪剂数字放射自显影技术，将用HM-PAO测量的LCBF与另外两种示踪剂[14C]碘安替比林（IAP）和[201Tl]二乙基二硫代氨基甲酸盐（DDC）的测量结果进行比较。HM-PAO的LCBF值平均为IAP的64%，且通常呈线性相关。详细分析表明，HM-PAO对LCBF的低估与血液成分结合和/或快速转化为非亲脑化合物以及非瞬时脑摄取有关，而非扩散限制。

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Quantitative local cerebral blood flow measurements with technetium-99m HM-PAO: evaluation using multiple radionuclide digital quantitative autoradiography.用锝-99m HM-PAO进行局部脑血流量定量测量：使用多放射性核素数字定量放射自显影术进行评估。
J Nucl Med. 1988 Aug;29(8):1387-92.
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