Hu Zhenxian, He Chenliang
Department of Ophthalmology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, China.
Oncotarget. 2017 Mar 28;8(13):21167-21176. doi: 10.18632/oncotarget.15504.
The aim of this meta-analysis was to evaluate the association between cyclin-dependent kinase Inhibitor-2B (CDKN2B) gene rs1063192 polymorphism and glaucoma risk. We searched the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 14 case-control studies involving 11,316 cases and 24,055 controls were included. Meta-analysis showed that CDKN2B gene rs1063192 polymorphism was associated with a decreased risk of glaucoma. Stratification analysis of ethnicity indicated that rs1063192 polymorphism decreased the risk of glaucoma among Caucasians and Asians. Stratification analysis by type of glaucoma revealed that rs1063192 polymorphism conferred a protective factor of primary open-angle glaucoma (POAG) and non-POAG. Stratification by source of controls uncovered an association between rs1063192 polymorphism and glaucoma in groups of population-based controls. In conclusion, this meta-analysis indicates that CDKN2B gene rs1063192 polymorphism is significantly associated with a decreased risk of glaucoma.
这项荟萃分析的目的是评估细胞周期蛋白依赖性激酶抑制剂2B（CDKN2B）基因rs1063192多态性与青光眼风险之间的关联。我们检索了PubMed和Embase数据库。使用固定效应或随机效应模型计算合并比值比（OR）和95%置信区间（CI）。共纳入14项病例对照研究，涉及11316例病例和24055例对照。荟萃分析表明，CDKN2B基因rs1063192多态性与青光眼风险降低相关。种族分层分析表明，rs1063192多态性降低了白种人和亚洲人患青光眼的风险。按青光眼类型进行的分层分析显示，rs1063192多态性是原发性开角型青光眼（POAG）和非POAG的保护因素。按对照来源进行分层发现，rs1063192多态性与基于人群对照的组中青光眼之间存在关联。总之，这项荟萃分析表明，CDKN2B基因rs1063192多态性与青光眼风险降低显著相关。
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