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利用分子成像推进药物发现与开发(ADDMI):世界分子成像协会的一个兴趣小组及正电子发射断层扫描(PET)的开幕会议。

Advancing Drug Discovery and Development Using Molecular Imaging (ADDMI): an Interest Group of the World Molecular Imaging Society and an Inaugural Session on Positron Emission Tomography (PET).

作者信息

Patel Shil, Schmidt Karl, Hesterman Jacob, Hoppin Jack

机构信息

Eisai AiM Institute, 4 Corporate Drive, Andover, MA, USA.

Celgene, 86 Morris Avenue, Summit, NJ, USA.

出版信息

Mol Imaging Biol. 2017 Jun;19(3):348-356. doi: 10.1007/s11307-017-1085-7.

Abstract

Multi-modality molecular imaging techniques have expanded the role of imaging biomarkers in the pharmaceutical industry and are beginning to streamline the drug discovery and development process. The World Molecular Imaging Society (WMIS) serves as a forum for discussing innovative and exploratory multi-modal, interdisciplinary molecular imaging research with a mission of bridging the gap between pathology and in vivo imaging. To formalize the role of the WMIS in pharmaceutical research efforts, members of the society have formed an interest group entitled Advancing Drug Discovery and Development using Molecular Imaging (ADDMI). The ADDMI interest group launched their efforts at the 2016 World Molecular Imaging Congress by hosting a session of invited lectures on translational positron emission tomography (PET) imaging in the central nervous system. This article provides a synopsis of those lectures and frames the role of translational imaging biomarker strategies in the drug discovery and development process.

摘要

多模态分子成像技术拓展了成像生物标志物在制药行业中的作用,并开始简化药物研发流程。世界分子成像协会(WMIS)作为一个讨论创新和探索性多模态、跨学科分子成像研究的论坛,其使命是弥合病理学与体内成像之间的差距。为了规范WMIS在药物研究工作中的作用,该协会成员成立了一个名为“利用分子成像推进药物发现与开发”(ADDMI)的兴趣小组。ADDMI兴趣小组在2016年世界分子成像大会上启动了相关工作,举办了一场关于中枢神经系统转化正电子发射断层扫描(PET)成像的特邀讲座。本文概述了这些讲座内容,并阐述了转化成像生物标志物策略在药物发现与开发过程中的作用。

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