[干扰素和肿瘤坏死因子对牛白血病病毒形成合胞体的抑制作用]
[Inhibitory effect of interferons and tumor necrosis factor on syncytium formation by bovine leukemia virus].
作者信息
Imanishi J, Ike H, Yamada A
机构信息
Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japan.
出版信息
C R Seances Soc Biol Fil. 1987;181(6):722-6.
The treatments of the bovine spleen cells BESp with recombinant human leukocyte interferon (HuIFN-alpha A) and human fibroblast interferon (HuIFN-beta) inhibit the syncytium formation by bovine leukemia virus (BLV) and the virus yield, depending on the IFN doses. But HuIFN-gamma did not inhibit the syncytium formation. The tumor-necrosis factor (TNF) also inhibits the syncytium formation and the virus yield, depending on the TNF doses. Furthermore, the combination of the HuIFN-alpha A with the TNF inhibits the syncytium formation more strongly than the HuIFN-alpha A alone or the TNF alone.
用重组人白细胞干扰素（HuIFN-αA）和人成纤维细胞干扰素（HuIFN-β）处理牛脾细胞BESp，可抑制牛白血病病毒（BLV）的合胞体形成和病毒产量，这取决于干扰素的剂量。但HuIFN-γ不抑制合胞体形成。肿瘤坏死因子（TNF）也可抑制合胞体形成和病毒产量，这取决于TNF的剂量。此外，HuIFN-αA与TNF联合使用比单独使用HuIFN-αA或单独使用TNF更能强烈抑制合胞体形成。
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