Dervan Edward, Lee Edward, Giubilato Antonio, Khanam Tina, Maghsoudlou Panayiotis, Morgan William H
Mater Misericordiae University Hospital, Dublin, Ireland.
Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia.
Clin Exp Ophthalmol. 2017 Nov;45(8):803-811. doi: 10.1111/ceo.12964. Epub 2017 Jun 5.
This study provides results of a treatment option for patients with failed primary glaucoma drainage device.
The study aimed to describe and evaluate the long-term intraocular pressure control and complications of a new technique joining a second glaucoma drainage device directly to an existing glaucoma drainage device termed 'piggyback drainage'.
This is a retrospective, interventional cohort study.
Eighteen eyes of 17 patients who underwent piggyback drainage between 2004 and 2013 inclusive have been studied. All patients had prior glaucoma drainage device with uncontrolled intraocular pressure.
The piggyback technique involved suturing a Baerveldt (250 or 350 mm) or Molteno3 glaucoma drainage device to an unused scleral quadrant and connecting the silicone tube to the primary plate bleb.
Failure of intraocular pressure control defined as an intraocular pressure greater than 21 mmHg on maximal therapy on two separate occasions or further intervention to control intraocular pressure.
The intraocular pressure was controlled in seven eyes (39%) at last follow-up with a mean follow-up time of 74.2 months. The mean preoperative intraocular pressure was 27.1 mmHg (95% confidence interval 23.8-30.3) compared with 18.4 mmHg (95% confidence interval 13.9-22.8) at last follow-up. The mean time to failure was 57.1 months (95% confidence interval 32.2-82), and the mean time to further surgery was 72.3 months (95% confidence interval 49.9-94.7). Lower preoperative intraocular pressure was associated with longer duration of intraocular pressure control (P = 0.048). If the intraocular pressure was controlled over 2 years, it continued to be controlled over the long term. Two eyes (11%) experienced corneal decompensation.
Piggyback drainage represents a viable surgical alternative for the treatment of patients with severe glaucoma with failing primary glaucoma drainage device, particularly in those at high risk of corneal decompensation.
本研究提供了针对原发性青光眼引流装置植入失败患者的一种治疗选择的结果。
本研究旨在描述和评估一种新技术的长期眼压控制情况及并发症,该技术将第二个青光眼引流装置直接连接到现有的青光眼引流装置上,称为“背驮式引流”。
这是一项回顾性干预队列研究。
对2004年至2013年(含)期间接受背驮式引流的17例患者的18只眼睛进行了研究。所有患者之前均植入了青光眼引流装置,但眼压控制不佳。
背驮式技术包括将一个Baerveldt(250或350mm)或Molteno3青光眼引流装置缝合到一个未使用的巩膜象限,并将硅胶管连接到原发性板层巩膜瓣。
眼压控制失败定义为在最大治疗方案下两次不同时间眼压大于21mmHg或需要进一步干预以控制眼压。
在最后一次随访时,7只眼睛(39%)的眼压得到控制,平均随访时间为74.2个月。术前平均眼压为27.1mmHg(95%置信区间23.8 - 30.3),而最后一次随访时为18.4mmHg(95%置信区间13.9 - 22.8)。平均失败时间为57.1个月(95%置信区间32.2 - 82),平均再次手术时间为72.3个月(95%置信区间49.9 - 94.7)。较低的术前眼压与较长的眼压控制持续时间相关(P = 0.048)。如果眼压在2年以上得到控制,则长期仍能保持控制。2只眼睛(11%)发生了角膜失代偿。
背驮式引流是治疗原发性青光眼引流装置植入失败的严重青光眼患者的一种可行的手术选择,特别是对于那些有角膜失代偿高风险的患者。